Nature: The Second Hospital of Zhejiang University discovered the secret of the relationship between the olfactory neural circuit and glioma

This is a problem that has plagued mankind for a long ti.

Gliomas are the most common malignant primary intracranial tumors, with a median survival of only 15 months from disease detection to dea.

In particular, the olfactory brain region is a predisposing site for gliom.

The researchers found that animals constantly receive a variety of sensory stimuli from their surroundings, such as smell, sound, light and tou.

"The growth of tumor cells communicates and transmits information with surrounding cel.

"The growth of tumor cells communicates and transmits information with surrounding cel.

"Since the olfactory brain region is a predisposing site for gliomas, will the neuronal activity of the olfactory circuit affect the occurrence of gliomas?" The team used chemogenetic intervention to precisely inhibit the activity of olfactory sensory neurons in mice and found that : After inhibiting the activity of olfactory sensory neurons, the tumor volume decreased significantly; after activating its activity, the tumor volume increas.

In order to verify the above conclusion, the team further blocked the unilateral olfactory input of mice through precise physical blocki.

"This discovery can help people better understand the nature of tumorigenesis, and provide a new direction for the prevention, early intervention and treatment of glio.

The research teams of the two parties have carried out long-term joint research and research on the origin, evolution process and influencing factors of brain malignant tumors, as well as specific therapeutic targets, and have obtained a series of eye-catching research resul.

What are brain malignancies?

What are brain malignancies?

Brain malignancy is a collective term for a series of central nervous system diseases represented by gliom.

Li Ao, a master of literature, was rebellious and authored all his li.

Beau Biden, the son of the current US President Biden, has long served as the state attorney gener.

What are the symptoms of a brain tumor?

What are the symptoms of a brain tumor?

The symptoms caused by gliomas mainly depend on their location and si.

Due to its impact on local brain tissue function, gliomas can also cause specific neurological deficits in patien.

Who is more likely to get glioma?

Who is more likely to get glioma?

Current research suggests that gliomas are caused by the interaction of congenital genetic risk factors and acquired environmental carcinogenic facto.

In addition, some environmental carcinogenic factors may also be associated with the occurrence of gliom.

Environmental risk factors for glioma that have been identified so far include exposure to high doses of ionizing radiation, nitrite foods, and viral or bacterial infectio.

How is glioma diagnosed?

How is glioma diagnosed?

The diagnosis of glioma should comprehensively consider the patient's medical history, symptoms, signs, auxiliary examinations and postoperative pathology to make a comprehensive judgme.

The most common tests for the diagnosis of glioma include head CT and magnetic resonance imaging (MR.

Head CT can preliminarily determine whether there is intracranial mass, and magnetic resonance can better show the location and nature of glio.

In addition, some special sequences of magnetic resonance imaging are often used in clinical work to distinguish gliomas from non-tumor lesions such as brain abscesses and brain inflammati.

How is glioma treated?

How is glioma treated?

Current treatments for gliomas include surgery, radiotherapy, chemotherapy, targeted therapy, and electric field thera.

Specifically, it is necessary to comprehensively consider factors such as the location and size of the glioma, the patient's neurological status, and the expected results of treatment to formulate an individualized comprehensive treatment pl.

According to the "Guidelines for the Diagnosis and Treatment of Glioma of the Central Nervous System in China", the treatment of glioma is mainly based on the safest tumor resection in the largest range, combined with comprehensive adjuvant therapy such as radiotherapy and chemothera.

In recent years, the Neurosurgery Center represented by the Neurosurgery of the Second Hospital of Zhejiang University has continued to advance clinical and basic research on glioma, and research results have continued to emer.

The diagnosis and treatment technologies and programs are changing with each passing day, and the goal of conquering gliomas is constantly striding forwa.

The Neurosurgery of the Second Hospital of Zhejiang University is the birthplace of neurosurgery and the cradle of neurosurgeons in Zhejiang Provin.

It is the clinical, teaching and scientific research center of neurosurgery in Zhejiang Provin.

It is also the Zhejiang Provincial Clinical Research Center for Neurological Diseases and the Zhejiang Provincial Key Laboratory of Precision Diagnosis, Treatment and Clinical Transformation of Neurosurgical Diseas.

As a first-class neurosurgery center in China, the Neurosurgery Department of the Second Hospital of Zhejiang University has established a total of 8 clinical subspecialties, with over 10,000 surgeries in 2021, standardized emergency treatment for cerebral aneurysms, minimally invasive surgery for pituitary tumors, precise surgery for functional area lesions, personalized treatment for gliomas, and emergency treatment for craniocerebral trau.

The rehabilitation system is at the leading and advanced level in Chi.

In the past five years, as the chief scientist unit, he has presided over 2 national key R&D projects and 35 projects of the National Natural Science Foundation of China, and has published in high-impact journals such as "Nature" (IF: 49) and "Immunity" (IF: 3
More than 100 papers with factors greater than 5 poin.

Original source:

Chen P, Wang W, Liu R, Lyu J, Zhang L, Li B, Qiu B, Tian A, Jiang W, Ying H, Jing R, Wang Q, Zhu K, Bai R, Zeng L, Duan S, Liu .

Olfactorysensoryexperienceregulatesgliomagenesis via neuronal IGF Natu.

2022 May 1 doi: 11038/s41586-022-04719-9

Chen P, Wang W, Liu R, Lyu J, Zhang L, Li B, Qiu B, Tian A, Jiang W, Ying H, Jing R, Wang Q, Zhu K, Bai R, Zeng L, Duan S, Liu .

Olfactorysensoryexperienceregulatesgliomagenesis via neuronal IGF Olfactory sensory experience regulates Natu.

2022 May 1 doi: 11038/s41586-022-04719-9 Leave a comment here