Nearly 500,000 people have studied: "ordinary" blood lipid detection looks like this, which can spy on the "heavenly machine" of dementia risk!

A recent publication from the Clinical Practice Research Datalink (CPRD) cohort suggests a modest association
between LDL cholesterol and dementia.
While LDL cholesterol remains an important lipid fraction when assessing general cardiovascular health, as well as brain health, other atherogenic lipoproteins such as apolipoprotein A (ApoA) and apolipoprotein B (ApoB).
), which was not evaluated
in this large-scale study.
Atherosclerogenic lipoprotein particles are important proteins in lipid metabolism that bind lipids (oil-soluble substances such as lipids and cholesterol) to form lipoproteins, and lipids can only enter the arterial wall
within the apolipoprotein particles.
In addition, it is estimated that the prevalence of dementia in women was higher than in men in 2019, and this advantage is expected to continue into 2050
.
Therefore, it is necessary to understand the underlying sex differences
in the biological mechanisms that lead to dementia.

Therefore, this study evaluated the comparative association of lipid traits with the risk of all-cause dementia, as well as by dementia subtypes (vascular dementia and Alzheimer's disease), and evaluated the potential effects
of sex-specific changes in large-scale UK biobanks.

From 2006 to 2010, the UK Biobank included 254575 women and 214891 men.

Cox regression estimated apolipoprotein A (ApoA), apolipoprotein B (ApoB), high-density lipoprotein, low-density lipoprotein, total cholesterol, triglycerides, lipoprotein A and overall and sex-risk ratios (HRs)
for various lipid ratios.

After 11.
8 years (median) follow-up, researchers recorded 3734 cases of all-cause dementia (1716 women 1231 AD and 929 VaD
.
The highest quartile of ApoA was associated with a lower risk of dementia compared to the corresponding lowest quartile (HR, [95% confidence interval (95% CI)]: 0.
77 [0.
69 to 0.
86]) , while the highest quartile of ApoB was associated with higher risk (HR, 1.
12 [1.
01 to 1.
24]).

The higher the HDL/ApoA and ApoB/ApoA, the higher the risk of dementia (HR, 1.
12 [1.
00, 1.
25], per SD, respectively).
1.
23 [1.
11,1.
37]) LDL/ApoB was negatively associated with dementia risk (0.
85 [0.
76 to 0.
94] per SD HR).

At age 60, high triglycerides were associated with a higher risk of dementia, but the opposite was
observed at age ≥ 60.
Similar associations
have been observed in VaD and AD.

Apolipoprotein and its proportions are associated
with the risk of dementia.
When assessing dementia risk, it may be wise
to consider apolipoprotein and circulating cholesterol.

Original source:

Jessica Gong, et al.
Serum lipid traits and the risk of dementia: A cohort study of 254,575 women and 214,891 men in the UK Biobank.
eClinicalMedicine 2022; 54: 101695 Published online xxx https://doi.
org/10.
1016/j.
eclinm.
2022.
101695