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A week ago, "5,800 people in the U.
S.
were still infected with the new crown after being vaccinated" were on the hot search.
As a result, Singularia saw a lot of media fanning the flames, saying that full vaccination would not work.
"Breakthrough infection" is about to strike.
However, these reports do not seem to take into account the base issue-when the US Centers for Disease Control and Prevention (CDC) released this data, 77 million people in the United States had completed two doses of mRNA vaccination, which means that people infected with the new crown after vaccination It only accounts for 0.
0075%, which is an incidence rate of 7.
5 per 100,000.
The protective efficacy of any vaccine is not 100%, and breakthrough infections are not surprising.
Only by clarifying the cause and finding a solution can the new crown vaccine better control the epidemic.
The two breakthrough infection cases reported by American scholars in the New England Journal of Medicine on the 21st provided clues for solving the problem [1].
Full vaccination is still the key to controlling the epidemic (Image source: Pixabay) These two female patients are both faculty and staff of Rockefeller University in New York.
They are usually in good health and have no previous medical history, but they were on the 19th after receiving the second dose of mRNA vaccine.
On the 36th day, he developed nasal congestion, headache and other typical symptoms of new coronary disease, and the infection was confirmed by nucleic acid testing.
Data provided by the US CDC shows that women account for 65% of breakthrough infections, so gender differences may be a point worth digging deeper.
However, both of them had mild symptoms and recovered within a week.
This also shows that the protective effect provided by the new crown vaccine, even if the vaccinator is really infected, the probability of serious consequences is relatively small.
Of the 5,800 breakthrough infections mentioned earlier in the United States, a total of 396 people required hospitalization and 74 died.
In order to further clarify the reason, the research team at Rockefeller University carried out strain sequencing and found that the two patients infected with the strains had three mutations of T95I, del142-144, and D614G, but the other mutations were not the same, especially the first place.
The patient’s strain has an E484K "immune escape mutation".
The "clinically relevant mutations" found in the sequencing of the two patients' virus strains.
From the overall situation of the virus strains, the two patients were infected with neither New York's recent local mutant strain B.
1.
526 nor the United Kingdom.
Mutant strains (B.
1.
1.
7) or South African mutant strains (B.
1.
351) that have significantly weakened the protective efficacy of multiple vaccines may be new variants in the "convergent evolution" of the new coronavirus.
The position of the infected strain of the first patient in the "evolutionary tree" of the new crown.
Tests on the serum of the first patient showed that the level of neutralizing antibodies was very high after vaccination, which was close to the level of more than one month after the new crown patient recovered.
The new crown vaccine The immune response should have been fully activated.
After vaccination, the patient’s neutralizing antibody levels were compared with those who had recovered from COVID-19, but the first patient’s COVID-19 virus load was also very high, reaching 195,000 copies per milliliter, much higher than the second patient’s 400 copies per milliliter.
Therefore, how the protective effect provided by the vaccine has been broken requires further confirmation, but this does not mean that the existing new crown vaccine is useless.
Recently, the CDC in the United States reported a clustered epidemic in an elderly care institution in Kentucky.
An unvaccinated employee was infected, resulting in 46 elderly people and employees in the nursing home being diagnosed, of which 22 were vaccinated with two doses of mRNA vaccine, but they appeared The risks of symptoms, hospitalization, and death are all significantly lower than those who have not been vaccinated [2].
The case report just released by the Chinese Center for Disease Control and Prevention analyzed an inspector from a hospital in Xi’an who was still diagnosed with the new crown after being vaccinated in March.
He also pointed out that “the patient’s symptoms are mild and the course of the disease is short.
This is most likely due to the new crown vaccine Vaccination"[3].
Therefore, the correct evaluation of the so-called "breakthrough infection" should be this: vaccination is indeed very useful, but it does not mean that it is foolproof.
After vaccination, the wave will start.
It is not advisable not to wear a mask and prevent and control it. Singularity Cake has become accustomed to wearing masks, and I think there is nothing wrong with it (Image source: Pixabay) What scientists and doctors have to do is continue to monitor the trend of mutant strains and adjust vaccines when necessary.
The latest released recently The data shows that the new mRNA vaccine developed for the mutant strain in South Africa is quite effective [4], and it is hoped that vaccine development can keep up with the mutation rate of the new coronavirus.
Singularity is hiring everyone! Everybody Hi~! We need fresh blood to inject new energy into the singularity.
Come on, become the singularity cake and do a new job with us! These are the little friends we are currently looking for~ If you want to create and innovate with the singularity cakes, come join us.
Please send your resume and work (if any) to: hr@geekheal.
com or you can directly add to the WeChat (geekheal-xintan) of Geekheal-xintan for communication.
When adding friends, please note: recruitment + position + professional field.
We are waiting for you at Singularity.
References: 1.
Hacisuleyman E, Hale C, Saito Y, et al.
Vaccine Breakthrough Infections with SARS-CoV-2 Variants[J].
New England Journal of Medicine, 2021.
2.
Cavanaugh AM, Fortier S, Lewis P, et al .
COVID-19 Outbreak Associated with a SARS-CoV-2 R.
1 Lineage Variant in a Skilled Nursing Facility After Vaccination Program — Kentucky, March 2021[J].
MMWR Morb Mortal Wkly Rep, 2021.
3.
Chaofeng M, Songtao X, Yecheng Y, et al.
Mild Breakthrough Infection in a Healthcare Professional Working in the Isolation Area of a Hospital Designated for Treating COVID-19 Patients — Shaanxi Province, China, March, 2021[J].
China CDC Weekly, 2021.
4.
https:// www.
biorxiv.
org/content/10.
1101/2021.
04.
13.
439482v1 Head image source: Pixabay Author of this article | Tan Shuo
S.
were still infected with the new crown after being vaccinated" were on the hot search.
As a result, Singularia saw a lot of media fanning the flames, saying that full vaccination would not work.
"Breakthrough infection" is about to strike.
However, these reports do not seem to take into account the base issue-when the US Centers for Disease Control and Prevention (CDC) released this data, 77 million people in the United States had completed two doses of mRNA vaccination, which means that people infected with the new crown after vaccination It only accounts for 0.
0075%, which is an incidence rate of 7.
5 per 100,000.
The protective efficacy of any vaccine is not 100%, and breakthrough infections are not surprising.
Only by clarifying the cause and finding a solution can the new crown vaccine better control the epidemic.
The two breakthrough infection cases reported by American scholars in the New England Journal of Medicine on the 21st provided clues for solving the problem [1].
Full vaccination is still the key to controlling the epidemic (Image source: Pixabay) These two female patients are both faculty and staff of Rockefeller University in New York.
They are usually in good health and have no previous medical history, but they were on the 19th after receiving the second dose of mRNA vaccine.
On the 36th day, he developed nasal congestion, headache and other typical symptoms of new coronary disease, and the infection was confirmed by nucleic acid testing.
Data provided by the US CDC shows that women account for 65% of breakthrough infections, so gender differences may be a point worth digging deeper.
However, both of them had mild symptoms and recovered within a week.
This also shows that the protective effect provided by the new crown vaccine, even if the vaccinator is really infected, the probability of serious consequences is relatively small.
Of the 5,800 breakthrough infections mentioned earlier in the United States, a total of 396 people required hospitalization and 74 died.
In order to further clarify the reason, the research team at Rockefeller University carried out strain sequencing and found that the two patients infected with the strains had three mutations of T95I, del142-144, and D614G, but the other mutations were not the same, especially the first place.
The patient’s strain has an E484K "immune escape mutation".
The "clinically relevant mutations" found in the sequencing of the two patients' virus strains.
From the overall situation of the virus strains, the two patients were infected with neither New York's recent local mutant strain B.
1.
526 nor the United Kingdom.
Mutant strains (B.
1.
1.
7) or South African mutant strains (B.
1.
351) that have significantly weakened the protective efficacy of multiple vaccines may be new variants in the "convergent evolution" of the new coronavirus.
The position of the infected strain of the first patient in the "evolutionary tree" of the new crown.
Tests on the serum of the first patient showed that the level of neutralizing antibodies was very high after vaccination, which was close to the level of more than one month after the new crown patient recovered.
The new crown vaccine The immune response should have been fully activated.
After vaccination, the patient’s neutralizing antibody levels were compared with those who had recovered from COVID-19, but the first patient’s COVID-19 virus load was also very high, reaching 195,000 copies per milliliter, much higher than the second patient’s 400 copies per milliliter.
Therefore, how the protective effect provided by the vaccine has been broken requires further confirmation, but this does not mean that the existing new crown vaccine is useless.
Recently, the CDC in the United States reported a clustered epidemic in an elderly care institution in Kentucky.
An unvaccinated employee was infected, resulting in 46 elderly people and employees in the nursing home being diagnosed, of which 22 were vaccinated with two doses of mRNA vaccine, but they appeared The risks of symptoms, hospitalization, and death are all significantly lower than those who have not been vaccinated [2].
The case report just released by the Chinese Center for Disease Control and Prevention analyzed an inspector from a hospital in Xi’an who was still diagnosed with the new crown after being vaccinated in March.
He also pointed out that “the patient’s symptoms are mild and the course of the disease is short.
This is most likely due to the new crown vaccine Vaccination"[3].
Therefore, the correct evaluation of the so-called "breakthrough infection" should be this: vaccination is indeed very useful, but it does not mean that it is foolproof.
After vaccination, the wave will start.
It is not advisable not to wear a mask and prevent and control it. Singularity Cake has become accustomed to wearing masks, and I think there is nothing wrong with it (Image source: Pixabay) What scientists and doctors have to do is continue to monitor the trend of mutant strains and adjust vaccines when necessary.
The latest released recently The data shows that the new mRNA vaccine developed for the mutant strain in South Africa is quite effective [4], and it is hoped that vaccine development can keep up with the mutation rate of the new coronavirus.
Singularity is hiring everyone! Everybody Hi~! We need fresh blood to inject new energy into the singularity.
Come on, become the singularity cake and do a new job with us! These are the little friends we are currently looking for~ If you want to create and innovate with the singularity cakes, come join us.
Please send your resume and work (if any) to: hr@geekheal.
com or you can directly add to the WeChat (geekheal-xintan) of Geekheal-xintan for communication.
When adding friends, please note: recruitment + position + professional field.
We are waiting for you at Singularity.
References: 1.
Hacisuleyman E, Hale C, Saito Y, et al.
Vaccine Breakthrough Infections with SARS-CoV-2 Variants[J].
New England Journal of Medicine, 2021.
2.
Cavanaugh AM, Fortier S, Lewis P, et al .
COVID-19 Outbreak Associated with a SARS-CoV-2 R.
1 Lineage Variant in a Skilled Nursing Facility After Vaccination Program — Kentucky, March 2021[J].
MMWR Morb Mortal Wkly Rep, 2021.
3.
Chaofeng M, Songtao X, Yecheng Y, et al.
Mild Breakthrough Infection in a Healthcare Professional Working in the Isolation Area of a Hospital Designated for Treating COVID-19 Patients — Shaanxi Province, China, March, 2021[J].
China CDC Weekly, 2021.
4.
https:// www.
biorxiv.
org/content/10.
1101/2021.
04.
13.
439482v1 Head image source: Pixabay Author of this article | Tan Shuo
