NEJM: Focused ultrasound therapy at the bottom of the pasum is used to improve resusciable motor symptoms in Parkinson's patients

Parkinson's disease is characterized by slow movement, stiffness, and resting tremors, and although there are many medications, difficult-to-treat motor symptoms, such as tremors and exercise complications, lead to a reduced quality of life.
neurosurgery target for the treatment of sports symptoms of Parkinson's disease with deep brain stimulation is in the hyaluralurology.
focused ultrasound is an imaging-guided method that can be used for the treatment of deep brain structures, including hyalthesis lesions.
people with Parkinson's disease who had obvious motor symptoms were involved in the study, the symptoms were not effectively controlled after receiving medication, and the patients were randomly treated with focused ultrasound or control.
the main endpoint of the study was 4 months later, without drug intervention, the World Society for Motor Disorders' Parkinson's Disease Comprehensive Assessment Scale (MDS-UPDRS) score changes (0-44, the higher the score, the more obvious the symptoms).
40 patients, 27 of whom received focused ultrasound therapy and 13 who received control.
4 months, the MDS-UPDRS score in the focused ultrasound treatment group decreased from 19.9 to 9.9 points, while the control group decreased from 18.7 to 17.1 points, with a difference of 8.1 points between the groups.
The main adverse events in focused ultrasound therapy were movement disorders (6 patients with movement disorders without drug intervention, 6 patients with movement disorders with drug intervention, 3 and 1 patients with persistent movement disorders after 4 months), fatigue (5 patients, 2 patients with persistent symptoms after 4 months), speech errors Disorder (15 patients, 3 of whom had persistent symptoms after 4 months), facial nerve paralysis (3 patients, 1 patient after 4 months had persistent symptoms) and gait disorder (13 patients, 2 of whom had persistent symptoms after 4 months), while 6 patients had adverse treatment reactions for 12 months.
focused ultrasound therapy at the bottom of the papycu brain can improve motor symptoms in people with Parkinson's disease, adverse reactions including speech and gait disorders, treatment side weakness, and movement disorders.
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