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NEJM: Oral small molecule drug Atogepant for preventive treatment of migraine

 Last Update: 2021-09-03
 Source: Internet
 Author: User

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Prevention Atogepant is an oral small molecule CGRP receptor antagonist.

In this phase III, double-blind study, adult patients with migraine attacks 4-14 days per month participated and were randomized to receive Atogepant treatment or placebo once a day for 12 weeks.

873 patients participated in the study, including 214 in the 10mg Atogepant treatment group

After 12 days of treatment, the average monthly migraine attack days in the 10, 30, and 60 mg Atogepant treatment group and the placebo group changed from baseline to -3.

Studies believe that oral small molecule CGRP inhibitor Atogepant can effectively reduce the number of days of migraine attacks.

Oral small molecule CGRP inhibitor Atogepant can effectively reduce the number of migraine attacks.

Original source:

Jessica Ailani et al.

Atogepant for the Preventive Treatment of Migraine.

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