Neural stem cells may be converted into blood vessels
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Last Update: 2020-12-08
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Source: Internet
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Author: User
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, published in the journal
, showed that neural stem cells from adult cervical arteries can be converted into neurons and blood vessels. This finding may have an impact on the development of treatments for diseases such as childhood tumors or Parkinson's diseases.
believe that neural stem cells have the ability to produce blood vessels, which will directly affect the growth of certain types of tumors in young children." Ricardo Pardal, lead researcher on the study at the University of Seville in Spain, said.
a small nerve structure located at the fork of the general artery of the neck. It functions like a natural chemical receptor that monitors blood oxygen levels and regulates breathing. The plasticity of adult stem cells or somatic cells has been a hot topic for nearly a decade. It has been known that neuroplastic stem cells (NCSCs) show significant plasticity in their development, but it is not yet known whether adult NCSCs cells retain plasticity.
to verify the plasticity of adult cervical arterial stem cells (CBSCs), researchers imported CBSCs from human neural sources into genetically modified mice with fluorescent markers. The results show that, in addition to its known role in nerve formation, CBSCs can also experience endothial cell differentiation, which helps organ nerves and angiogenesis in an oxygen-deprived environment.
addition, CBSCs are converted into vascular cells, depending on low oxygen induction factors (HIFs), and are sensitive to vascular cytokines released in hypoxia, such as erythrocytoples. "Our data highlight the physiological plasticity of tissue-specific stem cells in adult populations, or their use in cell therapy." Pardal said. (Source: Science.com)
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