NeuroImage: Neurometabolites are associated with personality and stress in healthy adults

Personality traits are related to both brain structure and function
.

However, the exact relationship between personality traits measured with proton magnetic resonance spectroscopy and other measures of neurometabolite behavior is unclear

Noora Tuovinen et al.
published a study in NeuroImage on the relationship between personality traits measured by proton magnetic resonance spectroscopy and other measures of neurometabolite behavior
.

The study analyzed behavioral measures of 57 healthy adults (26 women, mean age = 23.
40 years, SD = 2.
50) and the posterior cingulate cortex (pCC).
), metabolic ratios in the dorsal anterior cingulate cortex (dACC) and surrounding white matter (WM) regions (i.
e.
choline-containing compounds [Cho], creatine and phosphocreatine [Cr], N-acetylaspartate [NAA] ]) relationship
.

The pCC and dACC were selected because they are considered important brain network hubs and because they are associated with the five-factor personality dimension and other psychometric measures

Correlation of metabolite ratios with behavioral scores in pCC
.

Correlation of metabolite ratios with behavioral scores in pCC
.

The whole sample showed that stress was significantly negatively correlated with NAA/Cr ratio in pCC (p<0.
05), and extroversion was significantly negatively correlated with WM metabolic ratio (p<0.
05)
.

Stress was significantly negatively correlated with NAA/Cr ratio in pCC (p<0.
05), extroversion was significantly negatively correlated with WM metabolic ratio Metabolic ratios were significantly negatively correlated

Correlation of metabolite ratios in dACC with behavioral scores
.

Correlation of metabolite ratios in dACC with behavioral scores
.

Correlation of metabolite ratios in LFWM with behavioral scores  

Correlation of metabolite ratios in LFWM with behavioral scores  

             

             

Correlation of metabolite ratios with behavioral scores in LPWM
.

Correlation of metabolite ratios with behavioral scores in LPWM
.

Correlation of metabolite ratios in RFWM with behavioral scores

Correlation of metabolite ratios in RFWM with behavioral scores

The NAA/Cho ratio of female pCC, dACC and left and right posterior WM was significantly increased (p<0.
05), and the Cho/Cr ratio of dACC was significantly decreased (p<0.
01)
.

In addition, the two genders differed in metabolite associations of openness, conscientiousness, extraversion, agreeableness, neuroticism, stress, hopelessness, and self-esteem as well as predicted by multiple regression models

The NAA/Cho ratio of female pCC, dACC and left and right posterior WM was significantly increased (p<0.

In addition, the two genders differed in the metabolites of openness and conscientiousness of pCC, suggesting that psychological processes are involved through the DMN, while the affinity of dACC may be through participation in social cognitive processes, especially in women
.

The study also showed that the anterior cingulate gyrus is associated with so-called alpha personality factors
.

In addition, pCC may play a role in stress regulation, which may be related to stress, hopelessness, and self-esteem in male pCC, and higher self-esteem may help cope with stress

Anterior cingulate gyrus is associated with so-called alpha personality factors Anterior cingulate gyrus is associated with so-called alpha personality factors pCC may play a role in stress regulation processes, which may be related to stress, hopelessness and self-esteem in male pCC, higher self-esteem May help cope with stress pCC may play a role in stress regulation, which may be related to stress, hopelessness and self-esteem in male pCC, higher self-esteem may help cope with stress

original source

Neurometabolite correlates with personality and stress in healthy emerging adults: A focus on sex differences

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