Neurology: 25-year follow-up study finds cardiac structure and function associated with cognition in middle age

Studies have found a link between subclinical abnormalities in cardiac structure, systolic function, and diastolic function and low cognitive performance, especially in older adults; however, findings have been conflicting
.

The inconsistency could be explained by the selection of study populations with end-stage heart disease

Studies have found a link between subclinical abnormalities in cardiac structure, systolic function, and diastolic function and low cognitive performance, especially in older adults; however, findings have been conflicting

Laure Rouch et al.

The trial looked at 2653 participants (57% female, 46% black) from the Coronary Artery Risk Development in Young Adults (CARDIA) study
.

Echocardiograms to assess left ventricular (LV) mass (LVM), LV systolic function and LV ejection fraction (LVEF) and LV diastolic function with left atrial volume (LAV) and early peak mitral valve velocity (E)/early peak mitral annular velocity (e') ratio

The trial looked at 2653 participants (57% female, 46% black) from the Coronary Artery Risk Development in Young Adults (CARDIA) study

25 Average annual change (SD) in LVMi and LAVi increased by 0.
27 (0.

25-year change in echocardiographic parameters (slope)

25-year change in echocardiographic parameters (slope)

After adjusting for demographics and education level, an increase in LVMi (≥1 SD) at 25 years was associated with lower cognitive performance on most tests ( p≤ 0.

02);

After adjusting for demographics and education level, statistical 25 25 -year LVMi increase (≥1 SD) was associated with decreased cognitive performance on most tests ( p≤ 0.
02); annual LVMi increase (≥1 SD) was associated with cognitive decline on most tests related to reduced ability ( p≤ 0.

25 Increased LAVi at 25 years was associated with lower overall cognition (p= 0.

However, the reduction in LVEF at 25 years was not associated with cognition

Changes in cardiac structure and function and midlife cognition over 25 years

Changes in cardiac structure and function and midlife cognition over 25 years

Further adjustment for cardiovascular risk factors yielded similar results
.

Further adjustment for cardiovascular risk factors yielded similar results
.

Blood vessel

Furthermore, unlike E/e' ratio and LVEF at 30 years, higher LVMi and LAVi at 30 years were significantly associated with worse cognition on most cognitive tests
.

Furthermore, unlike E/e' ratio and LVEF at 30 years, higher LVMi and LAVi at 30 years were significantly associated with worse cognition on most cognitive tests
.

Higher 30-year LVMi and LAVi were significantly associated with worse cognition on most cognitive tests

Midlife Heart Structure and Function and Midlife Cognitive Heatmap

Midlife Heart Structure and Function and Midlife Cognitive Heatmap

Midlife cardiac structure and its changes from early to mid-adulthood were associated with lower midlife cognition , even after accounting for confounders
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Unlike systolic function, middle-aged LV diastolic function and its 25-year changes are also related to cognition
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Even after accounting for confounders, midlife cardiac structure and its changes from early to mid- adulthood were associated with lower midlife cognition age perception
.
Unlike systolic function, mid-life LV diastolic function and its 25-year changes are also related to cognition
.

original source

original source

Twenty-Five–Year Change in Cardiac Structure and Function and Midlife Cognition: The CARDIA Study.
Laure Rouch, Tina Hoang, Feng Xia, Stephen Sidney, Joao AC Lima, Kristine Yaffe.
Neurology Mar 2022, 98 (10) e1040-e1049; DOI: 10.
1212/WNL.
0000000000013249

Twenty-Five–Year Change in Cardiac Structure and Function and Midlife Cognition: The CARDIA Study.
Laure Rouch, Tina Hoang, Feng Xia, Stephen Sidney, Joao AC Lima, Kristine Yaffe.
Neurology Mar 2022, 98 (10) e1040-e1049; DOI: 10.
1212/WNL.
0000000000013249 Twenty-Five–Year Change in Cardiac Structure and Function and Midlife Cognition: The CARDIA Study.
Laure Rouch, Tina Hoang, Feng Xia, Stephen Sidney, Joao AC Lima, Kristine Yaffe.
Neurology Mar 2022, 98 (10) e1040-e1049; DOI: 10.
1212/WNL.
0000000000013249 Leave a message here