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Neurology: Academician Gu Dongfeng and Fuwai Hospital found that polygenic risk score can reflect the prognosis of stroke

 Last Update: 2021-06-29
 Source: Internet
 Author: User

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Deaths due to stroke are increasing the threat to global health

prevention

Brain stroke is a complex disease caused by genetic and environmental factors

The identification of these genetic variants in stroke GWAS diabetes provides an opportunity to assess whether genetic risk can lead to meaningful improvements in future risk prediction and stratification

PRS is very important to generate stroke in Chinese population

They used meta-analysis and large-scale GWAS to analyze stroke and stroke-related traits in East Asians.

The results showed that during a total of 367,750 person-years (with an average follow-up of 9.

Individuals with both high polygenic risk and family history showed a lifetime risk as high as 41.

In addition, compared with individuals with low polygenic risk, individuals with high polygenic risk have greater benefits in adhering to the ideal absolute risk reduction of fasting blood glucose and total cholesterol

Cholesterol, heart blood vessels

The significance of this study is that the discovered metaPRS has great potential in stratifying stroke risk and identifying individuals who may benefit more from maintaining ideal CVH

The discovered metaPRS has great potential in stratifying stroke risk and identifying individuals who may benefit more from maintaining ideal CVH

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