Neurology: Cancer rates and mortality rates in people with multiple sclerosis

In a recent study published in Neurology, an authoritative journal in the field of neurology, which aims to determine whether there is a difference in cancer risk in people with and without multiple sclerosis (MS), researchers used population-based data sources to compare morbidity and cancer-specific mortality in MS and matching populations.
researchers used population-based administrative data from Manitoba and Ontario, Canada, to conduct retrospective pairing cohort studies.
researchers used validated case definitions to identify MS cases and then selected five non-MS controls that matched each other in the year of birth, gender, and region.
researchers linked these cohorts to cancer registries and estimated the incidence of breast, colorectal and 13 other types of cancer.
for breast and colorectal cancer, the researchers built a Cox model that adjusted age, socioeconomic status at the regional level, region, year of birth queue, and colomy.
researchers used meta-analysis to summarize provincial findings.
researchers included 53,984 MS cases and 266,920 controls.
multivariative analysis showed no difference in inter-queue breast cancer risk (combined risk ratio of 0.92 (95% CI: 0.78-1.09)) or colorectal cancer (combined HR of 0.83 (95% CI:0.64-1.07).
of breast cancer and colorectal mortality did not differ between the two cohorts.
incidence and mortality of bladder cancer in the MS queue were higher.
the incidence of prostate, uterine and neurological cancers varied between MS and the matching population, there was no difference in mortality.
result, there was no difference in the incidence of breast and colorectal cancer in individuals with and without MS.
, however, the incidence of bladder cancer has increased.
that differences in the rates of certain cancers in the MS population may reflect some differences rather than real differences.
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