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Neurology: Cognitive impairment in COVID-19 patients is related to damage to brain function and structural connections

 Last Update: 2021-12-26
 Source: Internet
 Author: User

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Among COVID-19 patients, cognitive impairment (COVID-DoC) has become a serious complication
.

The prognosis and pathophysiology of COVID-DoC are still unclear, complicating the decision to continue life-sustaining treatment

COVID-19

Brian L Edlow et al.
published an article in Neurology, describing the natural history of COVID-DOC and studying its related brain connection spectrum
.

Neuroimaging characteristics and recovery of COVID-DoC patients
.

After screening 1,105 patients with new coronary pneumonia , 12 COVID-DoC patients were recruited
.

The median age is 63.

Coronavirus disease

Long-term functional outcomes in patients with COVID-DoC

10 COVID-DoC patients underwent advanced neuroimaging examination; compared with healthy controls, the brain function and structural connections of COVID-DoC patients were reduced, and the structural connections were comparable to patients with severe TBI
.

Functional connection of resting state between COVID-DoC patients and healthy controls

Diffusion-weighted MRI indicators of COVID-DoC patients and healthy controls

During the COVID-19 pandemic, COVID-DoC posed unique and profound challenges
.

COVID-DoC makes it impossible for patients to communicate, and the prospects for recovery are uncertain, forcing family members and clinicians to decide whether to continue life-sustaining treatment with little data to guide them

Patients who survive the medical complications of severe new coronary pneumonia are very likely to regain consciousness .

Disorders of Consciousness Associated With COVID-19: A Prospective, Multimodal Study of Recovery and Brain Connectivity

David Fischer, Samuel B Snider, Megan E Barra, William R Sanders, Otto Rapalino, Pamela Schaefer, Andrea S.

Neurology Dec 2021, 10.

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