Neurology: Dilation of the perivascular space is a biomarker for small vessel disease

The perivascular space is a cavity filled with cerebrospinal fluid around the penetrating arteries in the deep part of the brain
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When they expand, they can be seen on the MR image, which is then called perivascular space expansion (EVPS)

Blood vessel

The journal Neurology published research papers on the measurement of EPVS and SVD and AD in CSO, BG and HP (including clinical diagnosis , disease-related biological The relationship between markers and cognitive measures)
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And tested the correlation between EPVS and AD dementia samples with age and white matter lesion matching CU participants

The journal Neurology published research papers on the measurement of EPVS and SVD and AD in CSO, BG and HP (including clinical diagnosis , disease-related biological The relationship between markers and cognitive measures) .
And tested the correlation between EPVS and AD dementia samples with age and white matter lesion matching CU participants .
diagnosis

In order to study the relationship between perivascular space expansion (EPVS) and Alzheimer’s disease (AD), small vessel disease (SVD), cognition, vascular risk factors, and neuroinflammation, the study analyzed the EPVS is associated with different related neuroimaging, biochemistry and cognition
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The study included 499 Cognitive Accessibility (CU) patients, 240 patients with mild cognitive impairment and 39 patients with AD in the Swedish Early and Reliable Biomarker Identification of Neurodegenerative Diseases (BioFINDER) study
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Determine the CSO, BG, and hippocampal EPVS with a diameter> 1 mm in MRI; and collect hippocampal volume, white matter lesions (WML) and other SVD markers

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EPVS severity and WML volume Fazekas score
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Combining the WML volume (lg10 WML volume) of the CU and MCI samples and the Fazekas score of EPVS severity, the three levels of EPVS measurements for each anatomical area (panel AC) are displayed respectively

EPVS severity and WML volume Fazekas score

CSO , EPVS in BG and HP correlated with WML volume and Fazekas score in patients without dementia.

EPVS is also related to SVD in the early stage of the disease, which supports the hypothesis that EPVS is a marker of SVD, but does not support the role of EPVS in the early pathogenesis of AD

Association of Enlarged Perivascular Spaces and Measures of Small Vessel and Alzheimer Disease.

Association of Enlarged Perivascular Spaces and Measures of Small Vessel and Alzheimer Disease.
Eske Christiane Gertje, Danielle van Westen, Clara Panizo, Niklas Mattsson-Carlgren, Oskar Hansson.
Neurology Jan 2021, 96 (2) e193-e202; DOI: 10.
1212/WNL .
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