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Neurology: Don't Ignore!

 Last Update: 2022-03-05
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Cardiovascular risk factors have consistently been associated with a greater risk of cognitive impairment
.
Little is known about the relationship between heart structure and function, which are often markers of cumulative heart health, especially in middle age

Contrast echocardiography is a widely used non-invasive imaging method that measures left ventricular mass (LVM), left ventricular ejection fraction (LVEF), left atrial volume (LAV), and premature mitral valve velocity (e) /Mitral annular early peak velocity (e') ratio and other parameters to quantitatively measure cardiac structure and function

The Coronary Artery Risk Development in Young Adults Study (CARDIA) , a community-based prospective cohort study, provides a unique opportunity to explore the heart-brain connection in early adulthood
.
The study, published today in the journal Neurology, sought to examine changes in heart structure and function in midlife, and whether changes over a 25-year period from early to mid-adulthood are associated with cognitive decline in midlife

Coronary Artery Risk Development in Young Adults (CARDIA) The study , published in the journal Neurology, sought to investigate changes in heart structure and function in midlife, and whether changes over a 25-year period from early to mid-adulthood correlate with cognitive performance in midlife.

studied 2653 participants (57% female, 46% black) from the Young Hearts (Coronary Risk Development) study

2653

Over 25 years, the annual mean changes (sd) in LVMi and LAVi were 0.
27 g/m ² (0.
28) and 0.
42 ml/m ² (0.
15), respectively, and LVEF decreased by 0.
11% (0.
02)
.
Adjusted for demographic and educational factors, 25-year (≥1-sd) increase in LVMi was associated with lower cognitive levels on most tests (p ≤ 0.
02), and 25-year (p = 0.
04) increase in LAVi was associated with overall cognitive levels Lower (p = 0.
04), 25-year (≥1-sd) decline in LVEF was not associated with cognitive level
.
Further adjustment for cardiovascular risk factors led to similar results

.

Midlife cardiac structure and its changes in early to mid-adulthood were associated with cognitive decline in midlife, even after accounting for confounding factors

Source: Rouch , Laure et al.
“Twenty-Five-Year Change in Cardiac Structure and Function and Midlife Cognition: The CARDIA Study.
” Neurology, 10.
1212/WNL.
0000000000013249.
26 Jan.
2022, doi:10.
1212/WNL.
0000000000013249 Source: Rouch , Laure et al.
“Twenty-Five-Year Change in Cardiac Structure and Function and Midlife Cognition: The CARDIA Study.
” Neurology, 10.
1212/WNL.
0000000000013249.
26 Jan.
2022, doi:10.
1212/WNL .
0000000000013249 R leave a message here

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