Neurology: Incidence, prevalence, longitudinal damage and disability of small fiber neuropathy

According to reports, small fiber neuropathy (SFN) is a common disease, with a population prevalence of 53 per 100,000 in a large study

In the United States, a specific SFN ICD-10 diagnostic code (G628) has only recently been provided (October 2015)

Most of the early studies of SFN alone or in combination did not include longitudinal results, detailed neurological examination, or exclude patients who developed large fiber involvement

A study used the SF-36 questionnaire to check the quality of life and found that the physical function scores were significantly worse at the time of evaluation

In this way, Stephen A Johnson of the Mayo Clinic and others evaluated the incidence and prevalence of SFN patients without large fiber involvement (pure) at the time of onset, and longitudinally evaluated the patients’ comorbidities and cumulative nervous system from a population perspective.

They compared test-confirmed SFN patients in Olmsted, Minnesota and neighboring counties with a matched control group (January 1, 1998-December 31, 2017) 3:1

A total of 94 SFN patients were found, with an incidence rate of 1.

Compared with the control group (median 3, range 1-9), Charlson had more comorbidities (median 6, range 3-9), P<0.

17 people developed foot ulcers, 71% of them had DM

The median neuropathy impairment score (NIS) at onset is 2 (range 0 to 8), and the change/year is +1.

The proportion of SFN patients who died due to symptom onset was higher, 19%, compared with 12% in the control group, P<0.

The important significance of this study lies in the discovery: Isolated SFN is not common, but the incidence is increasing