Neurology: Long-term effects of cholinesterase inhibitors on cognitive decline and mortality

Recently, a research article was published in Neurology, an authoritative journal in the field of neurology, which aims to determine whether cholinesterase inhibitors (ChEIs) are related to the slowing down of cognitive function in Alzheimer’s dementia, severe dementia or death Related to the risk reduction.

The researchers included Alzheimer's dementia patients from the Swedish Dementia Registry (SveDem) who started ChEIs treatment within three months after the diagnosis of dementia, and conducted the study with untreated Alzheimer's dementia patients.

In a cohort with matching propensity scores, the researchers used a mixed model to evaluate the association between the use of CHEI and the cognitive trajectory assessed by the Mini Mental State Assessment Scale (MMSE) scores, and used the Cox proportional hazards model for severe dementia (MMSE).

The study included 11652 ChEI users and 5826 non-users.

It can be seen that ChEI is related to cognitive benefits and persists over time.

Hong Xu.