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Cerebral microbleeds (CMBs) are small (<10mm), low signal, oval or circular imaging findings found on T2*-weighted GRE or sensitivity-weighted imaging (SWI)
.
Pathologically, it mainly corresponds to the deposits rich in hemosiderin near the arterioles, which is considered to be the bleeding under the microscope reported in the past
Cerebral microhemorrhage
Many studies have analyzed the risk factors of CMBs
.
They believe that CMBs are related to a series of risk factors such as age, hypertension, obesity and diabetes
The sensitivity of MRI to CMBs is a complex issue, depending on many factors, including the scanner field strength, acquisition sequence, and whether to use gradient echo or more sensitive sensitivity weighting sequence (SWI), etc.
Many studies have adopted multiple Different scanners
.
In October 2021, Dongwei Lu from the University of Cambridge, UK, and others announced their research results on Neurology.
They used data from the UK Biobank to determine the relationship between the risk factors and CMBs of more than 8,000 healthy middle-aged and elderly people.
The relationship was studied
.
The MRI scans of the 8159 participants in the UK Biobank study were suitable for CMB analysis
.
Obtain brain SWI imaging data on two identical 3.
The average age at the time of scanning was 62.
1±7.
4 years
.
One or more clear CMBs were detected in 572 (7.
Age is an independent risk factor for CMBs in all regions
.
APOE4 is positively correlated with males and lobar CMBs, while higher body mass index is negatively correlated with lobar CMBs
In the end, the author believes that in this large-scale population study, the prevalence of CMB detected by a low-sensitivity and high-specificity detection system was 7%
.
The risk factors of lobes and deep CMBs are different, suggesting that there are different pathophysiological processes
Original source:
Original source:Dongwei Lu, Junfeng Liu, Andrew D.
Prevalence and Risk Factors of Cerebral Microbleeds: Analysis From the UK Biobank Leave a message here
