Neurology: The evidence of "Meng's mother's three migrations" is here!

Everyone has heard the story of "Mengmu's Three Moves", right? The three migrations of Meng Ke's mother means that Meng Ke's mother moved many times in order to choose a good environment to educate her children.

Recently, scientists have developed a deep interest in the cognition of the environmental impact of the neighborhood.

JAMA compared with the children of wealthy communities, children from poor communities in poor performance in a range of cognitive functions language skills, reading skills, memory and attention, cognitive brain capacity in key areas is also small.

Access to medium or large parks, beaches, and better street connectivity (decreased after adjusting neighborhood awareness).

The above-mentioned studies have provided more powerful evidence for urban planners and policy makers, proving that neighborhoods with good street connectivity and the existence of various scale parks nearby are beneficial to the recreational walking and health of local residents.

The above-mentioned studies have provided more powerful evidence for urban planners and policy makers, proving that neighborhoods with good street connectivity and the existence of various scale parks nearby are beneficial to the recreational walking and health of local residents.

prevention

Geocode the participant’s place of residence and rank it according to the environmental situation relative to the state of residence.

Among the middle-aged and elderly study population, participants who live in the worst 1/5 community (N=19) are closely related to the thinning of the cortex in the hallmark area of ​​AD and the decline of preclinical AD cognitive ability, especially The performance is particularly poor in the Trails-Making test, but the decline in the Rey auditory and speech learning test or the story memory delayed recall subtest is not obvious.

Participants living in 1/5 of the community with the worst relative environment (N=19) are closely related to the thinning of the cortex in the hallmark area of ​​AD and the decline of preclinical AD cognitive ability, and the worst 1/5 of the relative environment Participants living in the community (N=19) are closely related to the thinning of the cortex in the hallmark area of ​​AD and the decline of preclinical AD cognitive ability.

Further, after controlling for the racial and demographic differences between neighborhood-level disadvantaged groups, the above correlations are still significant.

The results of mediation analysis showed that cortex thinning partially mediates the relationship between the neighborhood environment and cognitive decline.

In summary, this study provides further evidence that the neighborhood environment affects neurodegeneration and cognitive decline.

references:

Association of Neighborhood Context, Cognitive Decline, and Cortical Change in an Unimpaired Cohort.

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