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Alzheimer's disease (AD) is a neurodegenerative disease that mainly occurs in the elderly.
The most basic and often earliest clinical manifestation of AD is selective memory impairment, but there are exceptions
The most basic and often earliest clinical manifestation of AD is selective memory impairment, but there are exceptions
In this single-center observational study, the researchers included all visits to the Alzheimer Center in Amsterdam, clinical diagnosis of subjective cognitive decline (SCD), mild cognitive impairment (MCI) or possible AD dementia and Individuals of A+
diagnosis
Results A total of 1524 A+ individuals were included from the Amsterdam dementia cohort, including A+ SCD (n = 113), A+ MCI (n = 321), and A+ AD dementia (n = 1,090)
NPS is common in all clinical AD stages (≥1 NPS, SCD is 81.
According to the clinical stage of AD, the prevalence of neuropsychiatric symptoms (NPS) in β-amyloid positive (A+) samples
Cognitive function showed a uniform gradual decline; on the contrary, in all AD groups, over time, a large intra-individual heterogeneity of NPS was observed
At baseline, it was found that the correlation between NPS and cognitive ability in dementia was the most obvious in NPI total score and MMSE (range β=-0.
In summary, neuropsychiatric symptoms and cognitive symptoms are common in the clinical spectrum of AD, and show different evolutions in the course of the disease
references:
Neuropsychiatric and Cognitive Symptoms Across the Alzheimer Disease Clinical Spectrum Cross-sectional and Longitudinal Associations.
Neuropsychiatric and Cognitive Symptoms Across the Alzheimer Disease Clinical Spectrum Cross-sectional and Longitudinal Associations.
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