Neurology: The performance of McDonald criteria revised in 2017 and 2010 in predicting MS diagnosis after clinically isolated syndrome

In 2001 , MRI was officially included in the diagnostic criteria for multiple sclerosis (MS) to show the spatial spread (DIS) and temporal spread (DIT) of multiple sclerosis lesions
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The subsequent update of the McDonald criteria simplified the diagnosis of multiple sclerosis while maintaining sensitivity, specificity and accuracy

2001 In2001 , MRI was officially included in the diagnostic criteria for multiple sclerosis (MS) to show the spatial spread (DIS) and temporal spread (DIT) of multiple sclerosis lesions

Recently, new evidence regarding the application of MRI and CSF analysis in the diagnosis of multiple sclerosis has emerged

Several aspects related to the performance of the McDonald standards revised in 2017 still need to be fully evaluated

785 patients with cerebral infarction from 9 centers in Europe underwent cerebrospinal fluid examination, brain and spinal magnetic resonance examination 5 months after the onset, and followed up with ≤ within 15 months of the onset
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The date of the second clinical onset and the date when the extended disability status score (≥) 3.

785 patients with cerebral infarction from 9 centers in Europe underwent cerebrospinal fluid examination, brain and spinal magnetic resonance examination 5 months after the onset, and followed up with ≤ within 15 months of the onset

• At follow-up (median 69.
  
  Compared with the McDonald criterion in 2010, the McDonald criterion in 2017 showed higher sensitivity, lower specificity and similar accuracy in predicting CDMS, while shortening the diagnosis time of MS
  
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