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Neurology: The relationship between the age of onset of multiple sclerosis patients and the abnormality of gray matter volume and white matter microstructure

 Last Update: 2021-11-01
 Source: Internet
 Author: User

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The clinical course of multiple sclerosis (MS) is related to age
.

An effective model to study the underlying pathophysiology is to compare childhood onset (before 18 years of age) (POMS) and adult onset (AOMS) patients, including a period of central nervous system activity and immune system maturity, to maximize the effect of age

Childhood Immunization

A previous study found that in AOMS patients whose POMS matches the duration of disease (DD), the early damage is more destructive, but the gray matter (GM) is better preserved.
Although the later disability is lower, the GM atrophy and White matter (WM) damage is more serious
.

Another study found that compared with AOMS patients whose age and DD were matched, POMS patients had more severe WM damage

Recently, studies have explored the influence of the age of onset on the microstructure abnormalities of gray matter volume (GMV) and white matter (WM) in adult patients with multiple sclerosis (MS) and its influence on the clinical phenotype and course of the disease

In this hypothesis-driven cross-sectional study, a total of 67 children with first-onset multiple sclerosis (POMS) and 143 adult multiple sclerosis (AOMS) patients with matching gender and disease course (DD) were recruited, and 208 were recruited.
Healthy controls
.

All subjects received neurological evaluation and 3T magnetic resonance imaging
.

MRI variables were standardized on the basis of healthy controls to eliminate the effects of age and gender

At DD=1 year, GMV and WM score anisotropy (FA) were abnormal in AOMS patients, while GMV and WM score anisotropy (FA) were not abnormal in POMS patients
.
In GMV and WM FA, there is a significant interaction between age of onset (POMS and AOMS) and DD
.

The intersection of the regression lines for POMS and AOMS patients is GMV DD 20 years and WM FA 14 years, respectively

Young patients initially have a certain degree of compensation for multiple sclerosis-related damage, and then the compensation mechanism begins to fail, loss of white matter integrity, then gray matter atrophy, and finally disability

https://n.
neurology.
org/content/early/2021/10/04/WNL.
0000000000012869.
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