Neurology: The relationship between the anatomical location of temporal lobe epilepsy surgery focus and the prognosis of postoperative epilepsy

Surgical treatment can cure temporal lobe epilepsy (TLE)
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However, 30%-40% of TLE patients still have seizures and lose consciousness after surgery

Surgical treatment can cure temporal lobe epilepsy (TLE)

In addition to clinical variables, the location and extent of anatomical resection are considered to be key factors in determining prognosis, and hippocampal resection is necessary for freedom of epilepsy

Voxel-based neuroimaging methods for lesion mapping have been widely used and improved to assess the quantitative relationship between brain injury and clinical variables other than epilepsy

Based on the evidence supporting the role of the medial temporal lobe cortex structure in TLE seizures , some researchers have recently hypothesized that the resection of the entorhinal and amygdala regions will be associated with further good postoperative results, and further hypothesized that the medial temporal bone structure and function are separated It is also independently related to better surgical results

Enrolled patients with drug-resistant temporal lobe epilepsy (TLE) from three epilepsy centers
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Voxel-based and connection-based mapping methods were used to determine the association between good results and surgically induced temporal lobe damage

Enrolled patients with drug-resistant temporal lobe epilepsy (TLE) from three epilepsy centers

• The cohort included 113 patients with TLE [54 women, 86 right-handed, 16.
  5 (SD=11.
  9) years old, 54.
  9% on the left side], and 61.
  1% of the patients had no disabling seizures at follow-up (Engel level 1)
  .
  
• Seizure tendency after TLE is related to the following 3 items: 1) Surgical damage to the hippocampus, almond-pyriform cortex complex and entorhinal cortex; 2) due to the loss of the hooked tract, anterior commissure, and white matter tract in the fornix Lead to the separation of temporal lobe, frontal area and marginal area; 3) Functional separation of frontal lobe (upper and middle frontal gyrus, orbitofrontal area) and temporal lobe (upper pole and middle pole)
  .
  

The cohort included 113 patients with TLE [54 women, 86 right-handed, 16.
5 (SD=11.
9) years old, 54.
9% on the left side], and 61.
1% of the patients had no disabling seizures at follow-up (Engel level 1)
.

The cohort included 113 patients with TLE [54 women, 86 right-handed, 16.
5 (SD=11.
9) years old, 54.
9% on the left side], and 61.
1% of the patients had no disabling seizures at follow-up (Engel level 1)
.

Seizure tendency after TLE is related to the following 3 items: 1) Surgical damage to the hippocampus, almond-pyriform cortex complex and entorhinal cortex; 2) due to the loss of the hooked tract, anterior commissure, and white matter tract in the fornix Lead to the separation of temporal lobe, frontal area and marginal area; 3) Functional separation of frontal lobe (upper and middle frontal gyrus, orbitofrontal area) and temporal lobe (upper pole and middle pole)

     Better freedom of postoperative epilepsy is related to surgical damage to specific structures and connections of the temporal lobe

Literature source: https://n.

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