Neuromodulation: Does long-term intrathecal injection of baclofen affect the memory function of patients with spasticity?

Spasticity is part of the upper motor neuron syndrome.
When spasticity restricts the patient's normal daily activities, affects the patient's basic life tasks, and generally reduces the quality of life, treatment is required
.

Medication is the most common treatment for severe cramps

However, related complications affect its utility

The purpose of this study is to investigate whether intrathecal injection of baclofen will affect the learning ability, memory and other advanced cognitive functions of patients with severe spasticity

In this study, 22 patients were recruited who plan to receive continuous chronic intrathecal baclofen (ITB) and provide informed consent to participate in the study
.

Only 11 patients with chronic SCI were able to complete the one-year follow-up (11 men, average age 41.

Psychological assessment is carried out in a course of treatment, which takes 2-3 hours, including clinical interviews, Webster’s Adult Intelligence Scale III; Auditory Language Learning Test (RAVLT)-immediate and delayed recall; Rey-Osterrith Complex Graph Test (ROCFT) ; Wechsler Memory Scale III, sub-test logical memory immediate and delayed recall; language fluency test (VFT)

Demographic characteristics of the patient

The demographic characteristics of the patient The demographic characteristics of the patient

During the entire study, no side effects of ITB drugs (for example, overdose, excessive weakness, lethargy, withdrawal syndrome) were observed
.

Long-term continuous administration of ITB can significantly alleviate the spasticity of patients with chronic SCI.

GABA-B receptor agonists have great potential and a variety of pharmacological effects, including anti-injury, muscle relaxation, and enhancement of synaptic plasticity

Neuropsychological manifestations of ITB pump system before and after implantation

Neuropsychological manifestations of ITB pump system before and after implantation

In short, no significant decrease in memory function was found
.

In addition, it was found that short-term auditory language memory and logical memory performance increased significantly

Štětkářová, I.

Štětkářová, I.

 

 

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