-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
- Cosmetic Ingredient
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
In recent years, evidence has shown that the brain's immune system and related inflammatory processes -- also known as "neuro-inflammation" -- contribute significantly to the development of Alzheimer's disease
.
With this in mind, the scientists analyzed various immune biomarkers, characterized by good detection power and reproducible results in the cerebrospinal fluid
"We found that some of these markers of inflammation were evident even in the absence of symptoms of dementia," Heneka said
.
"Based on the data we have at the moment, we can't be sure about the delivery time
extensive database
The starting point for the investigation was data from the so-called DELCODE study, in which the DZNE is working with several German university hospitals to study dementia and its early stages
.
The current research project includes findings from 300 men and women over the age of 60
Onset even without dementia
"Biomarkers for amyloid and tau have been established
.
These proteins accumulate in the brains of Alzheimer's patients and can also be detected in the cerebrospinal fluid
Evidence for neuroprotection
Two of the markers -- proteins belonging to the "TAM receptor family" -- appear to be involved in damage control programs
.
Among the study participants with high marker levels, who had relatively larger brain volumes, cognitive function declined more slowly over time
"Inflammatory processes are not bad per se, but are a normal protective response of the immune system to threatening stimuli, especially at the beginning
.
But they shouldn't last too long, so they need to be regulated," Heneka said
Frederic Brosseron, Anne Maass, Luca Kleineidam, Kishore Aravind Ravichandran, Pablo García González, Róisín M.
McManus, Christina Ising, Francesco Santarelli, Carl-Christian Kolbe, Lisa M.
