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    Home > Biochemistry News > Biotechnology News > Neuron dendrites help neurons perform complex calculations

    Neuron dendrites help neurons perform complex calculations

    • Last Update: 2022-03-02
    • Source: Internet
    • Author: User
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    In the human brain, neurons perform complex calculations on the information they receive


    The researchers found that within a single neuron, different types of dendrites receive input from different parts of the brain and process it differently


    In the neurons the researchers examined in this study, this dendritic processing appears to help cells take in visual information and combine it with motor feedback, a circuit involved in navigation and motor planning


    "Our hypothesis is that these neurons have the ability to pick out specific features and landmarks in the visual environment and combine them with information such as running speed, where I'm going, when to start, etc.


    Mathieu Lafourcade, a former MIT postdoc, is the lead author of the paper published today in the journal Neuron


    complex calculation

    Any given neuron can have dozens of dendrites, which receive synaptic input from other neurons


    Previous research has shown that dendrites can amplify incoming signals through specialized proteins called NMDA receptors


    This phenomenon, known as superlinearity, is thought to help neurons distinguish between inputs that are closer or farther apart in time or space, Harnett said


    In the new study, the MIT researchers wanted to determine whether different types of input target different types of dendrites, and if so, how that would affect the computations these neurons perform


    Harnett and his colleagues chose a part of the brain called the retrosplenial cortex (RSC) for their study because it is a good model of the correlative cortex


    In a study in mice, the researchers first showed that three distinct types of input enter the pyramidal neurons of the RSC: from the visual cortex to the basal dendrites, from the motor cortex to the apical oblique dendrites, and from the lateral thalamic nucleus (Visual Processing Zone) into clustered dendrites


    "Until now, there hasn't been a lot of mapping of which inputs go into these dendrites," Harnett said


    a series of reactions

    The researchers then measured the electrical activity in each compartment


    On the basal dendrites, the researchers saw what they expected: Input from the visual cortex stimulated ultralinear electrical spikes produced by NMDA receptors


    "It was shocking because no one had ever reported it before," Harnett said


    These linear inputs may represent information such as running speed or destination, while visual information entering the basal dendrites represents landmarks or other features of the environment, Harnett said


    In clustered dendrites receiving thalamic input, NMDA spikes appear to be generated, but not readily
    .
    Like apical oblique dendrites, clustered dendrites have a lower density of NMDA receptors
    .
    Harnett's lab is now studying what happens in all these different types of dendrites when mice perform navigation tasks
    .


    DOI

    10.
    1016/j.
    neuron.
    2022.
    01.
    025

    Article Title

    Differential dendritic integration of long-range inputs in association cortex via subcellular changes in synaptic AMPA-to-NMDA receptor ratio


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