Neuron: Dr. Zepeng Yao from the University of California, et al. report that the serotonin loop can regulate eating and energy balance

Serotonin, also known as serotonin (5-HT), is an important monoamine neurotransmitter

Serotonin, also known as serotonin (5-HT), is an important monoamine neurotransmitter

 

On January 19, 2022, Zepeng Yao ( Yao Zepeng ) and Kristin Scott of the University of California, Berkeley, published a research paper titled Serotonergic neurons translate taste detection into internal nutrient regulation in Neuron .

On January 19, 2022, Zepeng Yao ( Yao Zepeng ) and Kristin Scott of the University of California, Berkeley, published a research paper titled Serotonergic neurons translate taste detection into internal nutrient regulation in Neuron .

Similar to mammals, overall activation of serotonergic neurons in Drosophila strongly inhibits feeding [3,4]

Similar to mammals, overall activation of serotonergic neurons in Drosophila strongly inhibits feeding [3,4]

 

Figure 1: Schematic representation of clusters of serotonergic neurons in the Drosophila forebrain (modified from reference [3])

Figure 1: Schematic representation of clusters of serotonergic neurons in the Drosophila forebrain (modified from reference [3])

Using intravital calcium imaging, the researchers found that SEL neuronal clusters contained two distinct subtypes of serotonergic neurons

The researchers found that another group of serotonergic neurons, bitter-SELs, were not directly involved in the regulation of feeding

Thus, this study reveals that two serotonergic neuron subtypes utilize taste stimuli to predict future feeding and changes in energy in the body, and pre-regulate endocrine and digestive tract functions to maintain energy balance in the body

In future studies, the researchers plan to further elucidate the structural and functional diversity of serotonergic neurons, such as whether SEM neuron clusters (Fig.

Figure 2: Regulation of taste perception and physiological function by two distinct serotonergic neuron subtypes in Drosophila

Figure 2: Regulation of taste perception and physiological function by two distinct serotonergic neuron subtypes in Drosophila

Original link:

https://doi.

https://doi.
org/10.
1016/j.
neuron.
2021.
12.
028

Leave a comment here