Neuron: Special pain-sensitive peptide neurons can make the body love high-fat foods

2020 May 13 News /BioValleyBIOON / - high-calorie, high-energy food to get an endless series in modern society, recently, a published in the international Journal ofNeuronresearch report, scientists from the Max Planck Institute and other institutions through the study found that a special type of mouse brain or nerve cells to promote their high fat food intake, if the mouse hypothalamus called nociceptin neurons (nociceptinneurons) is activated, the mice will eat more high-fat foodsSource: MPIf.MetabolismResearchfrom the 1980s, the global population of obesity and obesity-related diseases (diabetesand the incidence of cardiovascular disease, etc.) rising, researchers analyzed using mouse to study the types of nerve cells to control body excessive intake of high calorie and high-energy foods, for this purpose, researchers administered mice fed fat diet closely monitored subsequently, researchers AlexanderJais represents only a high fat diet for 3 days sufficient nociceptin activity was detected in neuronal cells of mouse brain special areathen a series of experiments, the researchers to selectively remove the nociceptin neurons from hypothalamic arcuate nucleus area of ​​mice, these mice would not be so excessive intake of high fat diet , while its normal food intake is not affected, this neuron nociceptin control body capable of specifically high-fat food intake;genetic researchers mice
modification, using light to control its activity nociceptin hypothalamus neurons, the brain activation of these cells can lead to excessive food intake of an animal, activate neurons nociceptin inhibits specific neuromodulation body satiety active element, resulting in excessive food intake in mice

intake can interfere with high-calorie food, the body's energy balance and increase the intake of calories, and now people are always cheap, delicious and high-energy food surrounded the body with a brain will we really like the way these kinds of foods to operate, but researchers do not know why some people only the required amount of food intake itself, while others are not, nociceptin neuronal activity perhaps uncover this mystery important clues, which activates the body will promote excessive intake of food, which makes nociceptin neurons or to become a special target for the development of new measures to help prevent and treat obesityFinally, the researchersJais said the current pandemic COVID-19 would need to remind us always pay attention to obesity and related metabolic diseases, suchsuch as diabetes, which is a major risk factor affecting the health of the body, so a better understanding of how the body's central nervous system control of food intake is important for researchers concerned, especially for high-calorie, high-fat and high carbohydrate food intake (Biovalley Bioon.com) Original source: AlexanderJais, LarsPaeger, TamaraSotelo-Hitschfeld, etal PNOCARCNeuronsPromoteHyperphagiaandObesityuponHigh-Fat-DietFeeding , Neuron (2020) .DOI: 10.1016 / j.neuron.2020.03.022