Neuropathol Appl Neurobiol: The p-Tau protein in the entorhinal cortex may be a key factor in women's susceptibility to Alzheimer's disease

The incidence of Alzheimer's disease (AD) in women is two to three times that of men, even though women live longer after correction.

Neuropathol Appl Neurobiol Journal.

Research flow chart

The study first analyzed all post-death brains of all non-dementia "control groups" and AD donors collected from the brain bank (245 men and 403 women) to determine gender differences in AD characteristics.

Experiment 1.

Gender differences in neuropathological characteristics of Alzheimer's disease (AD) .

Gender differences in neuropathological features of Alzheimer's disease (AD) Significant differences in gender differences in neuropathological features of Alzheimer's disease (AD) (Braak stage: p≤0.

Thiosine staining and typical immunohistochemical staining were used to detect phosphorylated Tau protein (p-Tau), β-amyloid protein (Aβ) and Aβ42 in human entorhinal cortex.

immunity

After 80 years of age, women's tangles and amyloid scores are significantly higher than men.

After 80 years of age, women's tangles and amyloid scores are significantly higher than men.

The study provides further evidence that women are more likely to develop AD.

wiley.

wiley.
com/doi/full/10.
1111/nan.
12729" target="_blank" rel="noopener">Hu, Y.
-T.
, Boonstra, J.
, McGurran, H.
, Stormmesand, J.
, Sluiter, A.
, Balesar, R.
, Verwer, R.
, Swaab, D.
and Bao, A.
-M.
(2021), Sex differences in the neuropathological hallmarks of Alzheimer's disease: focus on cognitively intact elderly individuals.
Neuropathol Appl Neurobiol.
https://doi.
org/10.
1111/nan.
12729 Hu, Y.
-T.
, Boonstra, J.
, McGurran, H.
, Stormmesand, J.
, Sluiter, A.
, Balesar, R.
, Verwer, R.
, Swaab, D.
and Bao, A.
-M.
(2021), Sex differences in the neuropathological hallmarks of Alzheimer's disease: focus on cognitively intact elderly individuals.
Neuropathol Appl Neurobiol.
  https://doi.
org/10.
1111/nan.
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