-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
- Cosmetic Ingredient
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Text/Guangzhou Daily All-Media Reporter Zhou Jieying Correspondents Wu Xiaodan, Han Yurou, Zhou Lijuan and arsenic, isn't this the classic poison in costume dramas? But it is also a traditional Chinese medicine blindly, its main ingredient is commonly called "arsenic" in modern times, and its chemical name is "arsenic trioxide" (ATO)
.
A new research result participated by the Department of Hematology, Zhujiang Hospital of Southern Medical University, puts forward the latest treatment strategy for targeted "bionic delivery" of arsenic agents, which is expected to enter the clinic in the future, improve the curative effect and scope of application of leukemia, and reduce its toxic side effects
.
This research result, which brings new hope to the majority of leukemia patients, was published in the sub-issue of the international authoritative academic journal "Nature · Nanotechnology" on October 26.
This is also the international academic community's recognition of innovative breakthroughs in traditional Chinese medicine
.
Background: China's first arsenic treatment of leukemia leukemia is one of the top ten high-incidence malignant tumors in China, and the mortality rate among children and adults under 35 years old ranks first in malignant tumors
.
Clinically, chemotherapy is the main treatment for various types of leukemia
.
Professor Li Yuhua, director of the Department of Hematology, Zhujiang Hospital of Southern Medical University, introduced that currently, the main clinical medications include antimetabolites, alkylating agents, alkaloids, antibiotics, hormones, and arsenic trioxide (ATO) proposed by Chinese scholars
.
For various types of leukemia, different standard chemotherapy regimens have been established clinically.
Due to the off-target effects and toxic side effects of chemotherapy drugs, many complications are inevitable
.
Arsenic has a long history as a medicine in China.
As early as the Ming Dynasty, Li Shizhen mentioned the application of arsenic in the treatment of various purulent diseases and tuberculosis diseases in "Compendium of Materia Medica"
.
What is less known is that 45 years ago, arsenic trioxide (ATO) became China’s self-invented and the world’s first specific drug for the treatment of acute promyelocytic leukemia (APL), and it is still one of the most common first-line drugs for the treatment of APL.
.
Breakthrough: Ferritin "wraps" arsenic to target leukemia cells.
Li Yuhua said that although arsenic has been used in leukemia for decades, everyone knows that arsenic has toxic side effects, especially on the heart, which is extremely important for elderly patients.
Unfriendly
.
"Now the treatment of leukemia is rushed to cure.
Excessive toxic and side effects have greatly affected the curative effect and the quality of life of the patient
.
" In the past, because no clear target was found to accurately strike leukemia cells, arsenic was used in the treatment.
The dose is relatively large, and it is an "indiscriminate blow" to the human body
.
Targeted therapy is born to break through these limitations
.
In this study, the researchers worked hard to find the path and carrier for "Sinomao" arsenic to reach the leukemia target CD71
.
Li Yuhua introduced that Zhujiang Hospital has long been committed to targeted drugs and immunotherapy for leukemia.
The State Key Laboratory of Biochemical Engineering of the Institute of Process Engineering of the Chinese Academy of Sciences focuses on the research and development of biomedical nano-targeted preparations.
Both parties have confirmed CD71 (transferrin) in their preliminary work.
Receptor 1, TfR1) is stably and highly expressed in various types of leukemia cells, and further studies have found that it can be used as a universal target for leukemia cells
.
In addition, ferritin can be recognized by CD71 and is a natural targeting carrier material with great transformation potential
.
In order to improve the therapeutic effect of ATO and expand the indications, the two parties jointly proposed an innovative strategy using CD71 ligand ferritin as a drug carrier to achieve targeted delivery of ATO, significantly improve the efficacy of ATO in the treatment of leukemia, further reduce its side effects, and expand The type of leukemia used
.
"In layman's terms, the arsenic agent is wrapped with ferritin through technological means.
The leukemia cell surface antigen CD71 is like a'grasp'.
When it encounters ferritin, it will actively'grab' it, and the arsenic agent will smoothly sneak into the leukemia.
It is " killed " inside the cell
.
"Mice experiment results show that nano-arsenic can reach the target accurately through targeted bionic delivery, which can reduce the dose by 4.
9 times compared with traditional arsenic therapy to achieve the same curative effect, and it has the same effect on acute myeloid system.
Both leukemia and acute lymphoblastic leukemia are effective
.
In the future, the research team will continue to study other types of leukemia
.
Prospects: To promote clinical translational application as soon as possible.
On October 26, based on the broad-spectrum characteristics of CD71 specific and high expression in a variety of leukemia cells, a new strategy for using CD71 ligand ferritin as a drug carrier is proposed.
"Nature" (Nature) sub-issue (impact factor: 39.
211) published
.
The research team stated that the above results belong to pre-clinical studies, and the actual clinical efficacy still needs to be further verified
.
In view of the fact that ferritin is a human endogenous component and ATO is an approved drug, arsenic nano-targeted preparations have good clinical transformation potential
.
At present, the research team is cooperating to advance the follow-up R&D and transformation in accordance with relevant requirements
.
Li Yuhua believes that this research is expected to promote the clinical transformation and application of ATO in the treatment of leukemia and realize the modernization of traditional Chinese medicine
.
"Using modern science and technology to transform China’s traditional Chinese medicine industry can not only establish China’s own modern Chinese medicine research, development, and production system, and develop high-efficiency, quick-acting, long-acting, low-toxic and high-quality modern Chinese medicines, but also improve China’s medicine The technical level and market competitiveness of the product
.
With the development of life sciences in the 21st century and the world trend of returning to nature, the breakthrough of Chinese traditional medicine may become one of the new major contributions of the Chinese nation to the entire human race.
The modernization of Chinese medicine is a necessity for social development
.
”2020 Hot Articles Featured 1.
The cup is full! A full paper cup of hot coffee, full of plastic particles.
.
.
2.
US, British and Australian scientists "Natural Medicine" add forceful proof: the new crown virus is a natural evolution product, contingent Two origins.
.
.
3.
NEJM: The effects of intermittent fasting on health, aging and disease 4.
Insomnia can be cured within a year! The study found: To improve sleep, you may only need a heavy blanket 5.
New Harvard study: Only 12 minutes Vigorous exercise can bring huge metabolic benefits to health.
6.
The first human intervention experiment: 28 days of "feeling and rolling" in nature is enough to improve immunity.
7.
Junk food is "real rubbish"! It takes away the length of telomeres and makes people grow old faster! 8.
Cell puzzle: you can die if you don’t sleep! But the lethal changes are not in the brain, but in the intestines.
.
.
9.
"Nature Communications" super large scale Research: The level of iron in the blood is the key to health and aging! 10.
Unbelievable! Scientists reversed the “permanent” brain damage in animals overnight and restored the old brain to a young state.
.
.
.
A new research result participated by the Department of Hematology, Zhujiang Hospital of Southern Medical University, puts forward the latest treatment strategy for targeted "bionic delivery" of arsenic agents, which is expected to enter the clinic in the future, improve the curative effect and scope of application of leukemia, and reduce its toxic side effects
.
This research result, which brings new hope to the majority of leukemia patients, was published in the sub-issue of the international authoritative academic journal "Nature · Nanotechnology" on October 26.
This is also the international academic community's recognition of innovative breakthroughs in traditional Chinese medicine
.
Background: China's first arsenic treatment of leukemia leukemia is one of the top ten high-incidence malignant tumors in China, and the mortality rate among children and adults under 35 years old ranks first in malignant tumors
.
Clinically, chemotherapy is the main treatment for various types of leukemia
.
Professor Li Yuhua, director of the Department of Hematology, Zhujiang Hospital of Southern Medical University, introduced that currently, the main clinical medications include antimetabolites, alkylating agents, alkaloids, antibiotics, hormones, and arsenic trioxide (ATO) proposed by Chinese scholars
.
For various types of leukemia, different standard chemotherapy regimens have been established clinically.
Due to the off-target effects and toxic side effects of chemotherapy drugs, many complications are inevitable
.
Arsenic has a long history as a medicine in China.
As early as the Ming Dynasty, Li Shizhen mentioned the application of arsenic in the treatment of various purulent diseases and tuberculosis diseases in "Compendium of Materia Medica"
.
What is less known is that 45 years ago, arsenic trioxide (ATO) became China’s self-invented and the world’s first specific drug for the treatment of acute promyelocytic leukemia (APL), and it is still one of the most common first-line drugs for the treatment of APL.
.
Breakthrough: Ferritin "wraps" arsenic to target leukemia cells.
Li Yuhua said that although arsenic has been used in leukemia for decades, everyone knows that arsenic has toxic side effects, especially on the heart, which is extremely important for elderly patients.
Unfriendly
.
"Now the treatment of leukemia is rushed to cure.
Excessive toxic and side effects have greatly affected the curative effect and the quality of life of the patient
.
" In the past, because no clear target was found to accurately strike leukemia cells, arsenic was used in the treatment.
The dose is relatively large, and it is an "indiscriminate blow" to the human body
.
Targeted therapy is born to break through these limitations
.
In this study, the researchers worked hard to find the path and carrier for "Sinomao" arsenic to reach the leukemia target CD71
.
Li Yuhua introduced that Zhujiang Hospital has long been committed to targeted drugs and immunotherapy for leukemia.
The State Key Laboratory of Biochemical Engineering of the Institute of Process Engineering of the Chinese Academy of Sciences focuses on the research and development of biomedical nano-targeted preparations.
Both parties have confirmed CD71 (transferrin) in their preliminary work.
Receptor 1, TfR1) is stably and highly expressed in various types of leukemia cells, and further studies have found that it can be used as a universal target for leukemia cells
.
In addition, ferritin can be recognized by CD71 and is a natural targeting carrier material with great transformation potential
.
In order to improve the therapeutic effect of ATO and expand the indications, the two parties jointly proposed an innovative strategy using CD71 ligand ferritin as a drug carrier to achieve targeted delivery of ATO, significantly improve the efficacy of ATO in the treatment of leukemia, further reduce its side effects, and expand The type of leukemia used
.
"In layman's terms, the arsenic agent is wrapped with ferritin through technological means.
The leukemia cell surface antigen CD71 is like a'grasp'.
When it encounters ferritin, it will actively'grab' it, and the arsenic agent will smoothly sneak into the leukemia.
It is " killed " inside the cell
.
"Mice experiment results show that nano-arsenic can reach the target accurately through targeted bionic delivery, which can reduce the dose by 4.
9 times compared with traditional arsenic therapy to achieve the same curative effect, and it has the same effect on acute myeloid system.
Both leukemia and acute lymphoblastic leukemia are effective
.
In the future, the research team will continue to study other types of leukemia
.
Prospects: To promote clinical translational application as soon as possible.
On October 26, based on the broad-spectrum characteristics of CD71 specific and high expression in a variety of leukemia cells, a new strategy for using CD71 ligand ferritin as a drug carrier is proposed.
"Nature" (Nature) sub-issue (impact factor: 39.
211) published
.
The research team stated that the above results belong to pre-clinical studies, and the actual clinical efficacy still needs to be further verified
.
In view of the fact that ferritin is a human endogenous component and ATO is an approved drug, arsenic nano-targeted preparations have good clinical transformation potential
.
At present, the research team is cooperating to advance the follow-up R&D and transformation in accordance with relevant requirements
.
Li Yuhua believes that this research is expected to promote the clinical transformation and application of ATO in the treatment of leukemia and realize the modernization of traditional Chinese medicine
.
"Using modern science and technology to transform China’s traditional Chinese medicine industry can not only establish China’s own modern Chinese medicine research, development, and production system, and develop high-efficiency, quick-acting, long-acting, low-toxic and high-quality modern Chinese medicines, but also improve China’s medicine The technical level and market competitiveness of the product
.
With the development of life sciences in the 21st century and the world trend of returning to nature, the breakthrough of Chinese traditional medicine may become one of the new major contributions of the Chinese nation to the entire human race.
The modernization of Chinese medicine is a necessity for social development
.
”2020 Hot Articles Featured 1.
The cup is full! A full paper cup of hot coffee, full of plastic particles.
.
.
2.
US, British and Australian scientists "Natural Medicine" add forceful proof: the new crown virus is a natural evolution product, contingent Two origins.
.
.
3.
NEJM: The effects of intermittent fasting on health, aging and disease 4.
Insomnia can be cured within a year! The study found: To improve sleep, you may only need a heavy blanket 5.
New Harvard study: Only 12 minutes Vigorous exercise can bring huge metabolic benefits to health.
6.
The first human intervention experiment: 28 days of "feeling and rolling" in nature is enough to improve immunity.
7.
Junk food is "real rubbish"! It takes away the length of telomeres and makes people grow old faster! 8.
Cell puzzle: you can die if you don’t sleep! But the lethal changes are not in the brain, but in the intestines.
.
.
9.
"Nature Communications" super large scale Research: The level of iron in the blood is the key to health and aging! 10.
Unbelievable! Scientists reversed the “permanent” brain damage in animals overnight and restored the old brain to a young state.
.
.
