New coronavirus Omicron mutant strain RBD and receptor ACE2 crystal structure

Wang Xinquan, Tsinghua University School of Life Sciences, Structural Biology Advanced Innovation Center, and Biostructure Frontier Research Center Wang Xinquan, and Tsinghua University School of Medicine Zhang Linqi’s laboratory recently analyzed the crystal structure of the Omicron mutant RBD and receptor ACE2 complex with a resolution of 2.

Since the outbreak of the new crown epidemic, Wang Xinquan, Tsinghua University School of Life Sciences, Structural Biology Advanced Innovation Center, and Biostructure Frontier Research Center Wang Xinquan, and Zhang Linqi Laboratory of Tsinghua University School of Medicine have been involved in the relationship between the structure and function of the spike protein, and the neutralizing antibody epitope and role Close cooperation in the direction of mechanism, etc.

Liu Dongsheng’s laboratory quickly synthesized RBD gene fragments using new gene synthesis technology.

Figure 1: Left image: The crystal structure of Omicron RBD and receptor ACE2 complex

Figure 2: Left image: Changes in the binding ability of the spike protein from the wild cell surface (WT) and Omicron mutant strains to ACE2