New drugs are found to help block the synthesis of cholesterol

People with high cholesterol resistance to statins (http:// may soon have new treatment options, according to a new study The researchers explained that these new drugs (http:// help block the synthesis of cholesterol in blocked arteries (http:// The drugs target an enzyme called ATP citrate lyase (ACL), which is part of the body's "bad" LDL cholesterol production pathway Clinical trials (http:// showed that compared with statins, their LDL cholesterol concentration was reduced by an average of 20% to 30%, while new drugs such as PCSK9 inhibitors could reduce LDL cholesterol concentration by more than 50% Diphenyl ether acid does not seem to surpass the existing drug zetia on the market An early clinical trial showed that diphenyl ether acid and ezetimibe reduced LDL cholesterol by about 28% compared with placebo, and American Heart Association expert Eckel said he was not involved in the new study The researchers say the body uses ACLS further in the same cholesterol synthesis process, which also uses enzymes targeted by statins, known as HMGCR Researchers said a study of nearly 655000 people found that people's ACL and HMGCR scores were associated with similar patterns of LDL cholesterol levels and similar effects on heart disease risk based on those levels The researchers found that people with genetic variants that inhibit ACL have lower LDL cholesterol levels and a lower risk of heart health problems (http:// The American Heart Association / American Heart Association updated cholesterol treatment guidelines in 2018, focusing on statins, which are inexpensive and proven to be effective But AHA and ACC also allow ezetimibe and PCSK9 inhibitors to work in people who still have elevated cholesterol despite statins.