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Our genomes give our cells instructions that determine the highly specialized functions of each cell type
.
Information is sent through two different types of RNA molecules: coding RNA, which converts DNA into proteins, and noncoding RNA, which does not produce proteins
Since non-coding RNA molecules do not produce proteins, they have not been the focus of research in the past, even though they make up about 97% of the RNA in our bodies
.
However, certain proteins called RNA-binding proteins have been shown to play a key role in cancer because of their ability to affect several different properties of RNA molecules
"With the help of tissue material donated by liver cancer patients, we have been able to map the coding and non-coding parts of our genome to determine which RNA-binding proteins are highly present in liver cancer cells
.
" Karolinska, senior author of the study said Claudia Carter, a researcher in the college's Department of Microbiology, Tumor and Cell Biology
The research team conducted a more detailed study of the specific pairing of an RNA-binding protein (CCT3) and a lncRNA molecule (LINC00326)
.
Using advanced CRISPR technology, they were able to reduce and increase the amount of protein and lncRNA to see how it affected cancer cells
There are many more combinations to study
The researchers' findings provide insight into the interactions between RNA-binding proteins and lncRNA molecules and contribute to a better scientific understanding of their roles in tumors
.
"The activity of the CCT3-LINC00326 pair can already be used for the diagnosis and prognosis
of liver cancer," said Jonas Noslash, first author of the study and an investigator in Carter's group
.
"However, the understanding of this particular pairing is only the beginning, and we will continue to investigate more combinations of RNA-binding proteins and lncRNA molecules
Journal Reference :
Jonas Noslash;rskov Søndergaard, Christian Sommerauer, Ionut Atanasoai, Laura C Hinte, Keyi Geng, Giulia Guiducci, Lars Bräutigam, Myriam Aouadi, Lovorka Stojic, Isabel Barragan, Claudia Kutter.
CCT3-LINC00326 axis regulates hepatocarcinogenic lipid metabolism .
