New method can reduce the side effects of antibiotic treatment. Combination of erythromycin and antidote can protect beneficial intestinal bacteria

Science and Technology Daily reporter Li Shan Recently, an international research team led by German scientists analyzed the effects of 144 antibiotics on common human intestinal bacteria and proposed a new method that can reduce the negative impact of antibiotic treatment on the intestinal microbiota
.

Related results were published in the recent "Nature" magazine
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There is a complex community composed of different types of microorganisms and many viruses in the human intestine, which enables the human body to use nutrients more effectively and prevents pathogenic bacteria from adhering and colonizing in the intestine
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Antibiotics help treat bacterial infections, but they can also damage the beneficial microbiota
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This "collateral damage" usually manifests as gastrointestinal discomfort, recurrent Clostridium difficile infection, related allergies, and metabolic, immune or inflammatory diseases
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Dr.
Tipas, a senior scientist at the European Molecular Biology Laboratory, said: “So far, people are still unclear about the impact of various antibiotics on individuals in the gut microbial community.
Which types of bacteria are affected are important
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" Based on earlier research, the team studied how each of 144 antibiotics affects the growth and survival of 27 common bacteria in the intestine
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They determined the effect of specific antibiotics on the concentration of bacterial strains, involving more than 800 combinations of antibiotics and strains
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Experiments have shown that the two commonly used antibiotics, tetracyclines and macrolide antibiotics, can not only prevent the growth of bacteria, but also cause their death
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This can explain the profound changes in the gut microbiota of some patients after antibiotic treatment
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　　The research team further proposed ways to reduce the negative impact of antibiotics on the gut microbiota
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They combined antibiotics such as erythromycin or doxycycline with nearly 1,200 drugs, and finally discovered several non-antibiotic drugs that can protect these intestinal bacteria
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Subsequent experiments show that this method is also applicable to the natural microbiome
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They demonstrated that the combination of erythromycin and antidote reduced the loss of certain types of intestinal bacteria in the intestines of mice
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　　Researchers also need further research to determine the best combination, dosage and formulation of antidote, and to rule out possible long-term effects on the gut microbiota
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In the future, this new method can help keep the gut microbiota healthy and reduce the side effects of antibiotics on patients without affecting the effectiveness of antibiotics
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