New methods for efficient inactivation of coronaviruses have progressed

New methods for efficient inactivation of coronaviruses have progressed

New methods for efficient inactivation of coronaviruses have progressed New methods for efficient inactivation of coronaviruses have progressed

"New membrane-targeted aggregation-induced luminescence (AIE) photosensitizer for efficient inactivation of human coronavirus" was selected as the back cover of Small
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Photo courtesy of Wuhan University

"New membrane-targeted aggregation-induced luminescence (AIE) photosensitizer for efficient inactivation of human coronavirus" was selected as the back cover of Small

Small

The topic of the thesis is "New membrane-targeted aggregation-induced luminescence (AIE) photosensitizer for efficient inactivation of human coronavirus"
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Chen Sijie's group from Liu Mingwei Rehabilitation Medicine Center of Caroline Medical College, Sweden, and Zhao Engui's group from Harbin Institute of Technology (Shenzhen) School of Science participated in the research

The new coronary pneumonia (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seriously threatens human health and life
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Viruses on high contact surfaces are an important route of transmission

Human coronaviruses (including new coronaviruses) are a type of enveloped viruses whose capsid and genetic material are covered with a lipid bilayer to provide additional protection
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Since the virus surface protein is different in different human coronavirus species and mutants, the lipid envelope may be a conservative target for photosensitizers

At room temperature, DTTPB can inactivate all human coronavirus HCoV-229E at 800 nM under the condition of 9 mW/cm2 white light irradiation for 20 minutes
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Not only that, DTTPB has very low cytotoxicity and excellent biocompatibility

This study is the first report of using AIE-specific membrane-targeted photosensitizers to inactivate human coronaviruses by photodynamic force, and provides a new prevention strategy for the control of the situation in the fight against new coronary pneumonia and the disease pandemic
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(Source: China Science News, Wen Caifei and Yang Peng)

Related paper information: https://doi.

https://doi.
org/10.
1002/smll.
202101770