Science and Technology Daily, Beijing, June 23 (intern reporter Zhang Jiaxin) Although no one knows which virus may cause the next epidemic, after the SARS outbreak caused by the coronavirus and the global new crown pneumonia pandemic, people realized that the coronavirus is harmful to humans.
The paper stated that the three coronaviruses that caused SARS in 2003, Middle East Respiratory Syndrome in 2012, and the outbreak of the new crown in 2019 all belong to the Sarbe coronavirus subgenus (Sarbecovirus)
To test this hypothesis, the researchers used chimeric spikes to prepare a nucleoside modified mRNA-lipid nanoparticle (LNP) vaccine
Experiments have found that after vaccinating mice with this vaccine, neutralizing antibodies against multiple spike proteins are effectively produced.
The neutralizing antibody of the chimeric spike mRNA vaccine is more active, effectively neutralizing the new coronavirus carrying the D614G mutation, the mutant new coronavirus in mink, the first alpha mutant new coronavirus discovered in the UK and the first beta mutation discovered in South Africa New crown virus
"Our discovery has a bright future because it shows that people can design more universal pan-coronavirus vaccines to proactively prevent viruses that may infect humans
Focus on the new crown pneumonia epidemic
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