New nanodevices can be used for pancreatic tumor diagnosis and targeted therapy

New nanodevices can be used for pancreatic tumor diagnosis and targeted therapy

New nanodevices can be used for pancreatic tumor diagnosis and targeted therapy New nanodevices can be used for pancreatic tumor diagnosis and targeted therapy

Material design concept, courtesy of Huazhong Agricultural University

Material design concept, courtesy of Huazhong Agricultural University

Recently, the "Advanced Materials and Green Catalysis" research team led by professors Chen Hao and Wang Shengyao of the Faculty of Science of Huazhong Agricultural University and the team of Professor Wang Hao of the National Nanoscience Center designed a peptide-semiconductor hybrid for the "king of cancer" pancreatic cancer.
Biochemical signal processor (BSP) for pancreatic tumor photoacoustic imaging and mitochondrial targeted sonodynamic therapy
.

Related research results are published online in Nano Today

Nano Today

In cancer treatment, it is an effective method to convert the energy of radiation or non-radiation waves into reactive oxygen species (ROS) through semiconductor nanomaterials to induce tumor cell apoptosis
.

The redox state of pancreatic cancer cells and their sensitivity to ROS are usually different from normal cells

As the basic material of the modern information society, semiconductor materials are excellent receivers and converters of various light, sound, and electrical signals
.

In this study, the synthesized polypeptide-semiconductor hybrid biosignal processor (BSP) is composed of oxygen-rich bismuth oxychloride semiconductor nanosheets (OV-Bi NSs) and two targeting peptides (PTP and CRK) Hybrid, in which the PTP polypeptide can specifically recognize the lectin-1 on the surface of pancreatic cancer cells (panc-1); and the CRK peptide is a targeting peptide of the mitochondrial protein p32 to promote the tight binding of BSP and mitochondria

Due to the rich oxygen vacancies, BSP has good near-infrared absorption and excellent photoacoustic imaging capabilities, and BSP surface targeting peptides endow BSP with the ability to recognize special protein signals in the pathological environment
.

Therefore, BSP has both protein signal recognition capabilities, photoacoustic signal feedback capabilities and active oxygen signal output capabilities.

Further in vitro and in vivo experimental studies have shown that the BSP nano signal processor integrates the protein signal recognition ability of polypeptide molecules and the physical signal conversion ability of semiconductor materials.
It can accurately identify pancreatic cancer protein signals and target pancreatic cancer cell mitochondria.
So as to effectively realize the photoacoustic imaging and sonodynamic therapy of pancreatic cancer, it provides new ideas for the development of intelligent devices for the diagnosis and treatment of pancreatic cancer
.

The research was funded by the National Natural Science Foundation of China and other projects
.

(Source: China Science News Li Chen)

Related paper information: https://doi.

https://doi.
org/10.
1016/j.
nantod.
2021.
101285