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The discovery of natural and engineered light-sensitive proteins has developed a universal and easy-to-use method in neuroscience, called optogenetics, which uses light stimulation to precisely adjust the time and space of neural activity, and is useful for understanding neural networks and neurons.
Functions and signal pathways have had a huge impact
.
Scientists at Ruhr University in Bochum, Germany have now discovered a new optogenetic tool and proved its potential in epilepsy research
.
This tool is a member of the opsin family found in the zebrafish brain and eyes, and it continuously activates an important intracellular signaling pathway called the Gi/o pathway
Different from other optogenetic proteins, this protein (Opn7b) will be turned off by blue or green light when light shines on them
.
Scientists reported on the properties of Opn7b in an article in "Nature Communications", "Reverse optogenetics of the G protein signal of the zebrafish non-visual opsin Opn7b to achieve synchronization of neuronal networks", which will allow The researchers temporarily interrupted the continuously active Gi/o signaling pathway by emitting blue or green light on Opn7b
The author pointed out: "This shows that light, as an inverse agonist of Opn7b, can be used as an optogenetic tool to inhibit neuronal networks in the dark and interrupt constitutive inhibition in light
.
"
The author points out: "In all epilepsy models so far, epilepsy induction is time-consuming, requires a long-lasting photoactivation scheme, and seizures are unreliable
.
" Researchers Dr.
