New organ chip discovers key interaction between blood and ovarian cancer tumor

In the continuous development of the field of cancer biology and treatment, the innovation of organ-on-chip microdevices enables researchers to discover more diseases outside the human body

The team recently submitted a patent document to the Engineering Experiment Station of Texas A&M University

Dr.

Jain's device-the Ovarian Tumor Microenvironment Chip (OTME-Chip)-focuses on platelets, which are tiny blood cells that help the body form clots to stop bleeding

Jain said: "We are using the organ-on-chip method to create a platform technology, in which tumor biology can be developed, and new drugs can be used under the influence of blood flow, supporting blood vessels, and extracellular matrix.

Surveillance of ovarian cancer is particularly challenging

OTME-Chip is based on current clinical observations to understand how platelets move within tumor tissues and what triggers them to spread outside the tumor

Jain said: "For the first time, we have confirmed the key interaction between platelets and tumors through surface proteins

The team includes postdoctoral doctor Biswajit Saha and PhD students Jim Tronolone and Tanmay Mathur

Jain said that OTME-Chip has a variety of applications.

"This multi-modal OTME-Chip will provide an ideal platform for healthcare researchers to evaluate the human-level tumor microenvironment created by their anti-cancer, vascular and blood drugs alone or in combination

Jain collaborates with Dr.

"Sood is a leader in the field of ovarian cancer," Jain said

Human tumor microenvironment chip evaluates the consequences of platelet extravasation and combinatorial antitumor-antiplatelet therapy in ovarian cancer

# # #

Video link: https:// description: This video shows how the Ovarian Tumor Microenvironment Chip (OTME-Chip) allows researchers to observe cancer cells, blood vessels and platelets in vitro
.

Video source: Dr.
Abhishek Jain / Texas A&M University College of Engineering