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New progress in lipid nanoparticles technology for targeted delivery of mRNA into lung tissue

 Last Update: 2022-04-30
 Source: Internet
 Author: User

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Lipid nanoparticles (LNPs) are currently two widely used delivery vehicles for mRNA COVID-19 vaccines

It has been shown that by changing the structure of the lipid molecules that make up LNPs, the specificity of their targeting to tissues can be altered

Further research found that when lung-targeting LNPs enter the bloodstream, they cause specific plasma proteins to attach to the surface of the LNPs, giving them the ability to target lung tissue

To further verify the role of this LNP, the researchers used it to deliver mRNA encoding the normal Tsc2 gene to mice with lymphangioleiomyomatosis due to an inactivating mutation in the Tsc2 gene

References:

[1] Targeting gene therapy directly into the lungs.

[2] Qiu et al.

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