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New progress in targeted therapy of pancreatic cancer |
Science and Technology Daily News (Reporter Liu Zhiwei, Correspondent Jiang Chaochang) On September 20, the reporter learned from Huazhong Agricultural University that the "Advanced Materials and Green Catalysis" research team led by Professor Chen Hao and Professor Wang Shengyao from the School of Science and the National Nanoscience Center Wang Hao The professor team worked together to design a polypeptide-semiconductor hybrid biosignal processor (BSP) for pancreatic cancer, the "king of cancer", for pancreatic tumor photoacoustic imaging and mitochondrial targeted sonodynamic therapy
.
Related research results were recently published online in "Nano Today" magazine
In cancer treatment, it is an effective method to convert the energy of radiation or non-radiation waves into reactive oxygen species (ROS) through semiconductor nanomaterials to induce tumor cell apoptosis
.
The redox state of pancreatic cancer cells and their sensitivity to ROS are usually different from normal cells
As the basic material of the modern information society, semiconductor materials are excellent receivers and converters for various light, sound, and electrical signals
.
In this study, researchers designed and synthesized BSP, which is composed of bismuth oxychloride semiconductor nanosheets rich in oxygen vacancies and two targeting peptides, PTP and CRK.
Further in vitro and in vivo experimental studies have shown that BSP integrates the protein signal recognition ability of polypeptide molecules and the physical signal conversion ability of semiconductor materials.