New progress in the study of the mechanism of bacterial constic compound sedative

The cheming of microorganisms refers to the behavior of bacteria that appear to approach or stay away from chemicalsubstances in the environmentThe proximity of nutrients or the distance away from harmful substances gives bacteria the ability to actively occupy an enabling environment, thus increasing their survival advantagesMethyl-receiving chemotaxis protein (MCP) is one of the key proteins in microbial cell sensing chemical signals in the external environment, MCP usually passes through the cell membrane, partly in the cell peripheral (periplasma), the other part is located in the cell mass, its part in the cell circumlorate can sense the external chemical signal, and thus regulate the activity of its downstream bi-component signal system, and ultimately change the direction of the rotation of the bacteria whiparomatic compounds are widely available in the environment, such as industrial and agricultural waste, plant root secretions, etc., microorganisms can grow as a carbon source, and many bacteria such as pseudomonas, Burke's bacteria and rhybobacteria have the ability to age aromatic compoundsPrevious studies have shown that bacteria can indirectly sense aromatic compound concentration levels through MCP sensing of small molecular compounds such as cyanic acid sepsis, and eventually the generalization of aromatic compounds (Ni et al2013, Mol Microbiol 90: 813-823)In addition, based on long-term experimental observations and analysis, scientists have speculated that bacteria can also directly sense aromatic compounds in the environment, but MCPs that bind directly to aromatic compounds and activate the chemersignaling pathway have not been found or reportedComamonas bupriad CNB-1 degrades a variety of aromatic contaminants and works with plants to repair chlorine-contaminated soils, as well as the ability to age on a variety of aromatic compounds in the environmentLiu Shuangjiang Research Group of the Institute of Microbiology of the Chinese Academy of Sciences, taking CNB-1 as the research object, carried out the research work on the modernization of aromatic compounds by microorganisms, and on the basis of the preliminary work, found a methyl receptor cheming protein that can be directly combined with aromatic compounds such as 2,6-dihydrobenzin, 2 hydroxyl benzoic acid, named MCP2901, and further used Nanodisc technology to reconstruct the signalization signal conduction systemMCP2901 is the first methyl receptor chemator protein that can be directly bound to aromatic compounds, and the discovery provides a basis for in-depth understanding of CNB-1's behavior between plant roots and the design of intelligent environmental microbial technology, as well as new biomaterials for the development of biosensors to detect aromatic compoundsthe project is supported by nIs, and the results have been published online in MicroMolecularbiologyRelated to the paper: "text-align: center;"img src""alt""bacterial research on aromatic compounds' cheming mechanisms"title""bacterial-aromatic compounds-contendation mechanism research": Figure: Microbes can sense aromatic compounds in the environment, with chemo-efficiencyBy using the characteristics of microorganisms to the aromatic pollutants, we can design intelligent microorganisms that actively look for pollutants and develop intelligent environmental microbial technologySource: Institute of Microbiology, Chinese Academy of Sciences