New protein produced by the United States reveals the way of cancer formation

Researchers at Yale University use the internal mechanism of cells to make a new protein that can cause cancer in mice but has not been found in nature, the physicist organization network reported recently This study not only revealed the formation of cancer, but also elucidated a new and effective method to produce proteins for industrial and medical applications The process of cancer formation is that a single cell changes abnormally and transforms into a cancer cell Then the cancer cell multiplies and forms Soon, the tumor begins to grow larger and compress the surrounding tissue The tumor spreads to the whole body Fortunately, the human body itself has the ability to discover and repair or resist and change mutated cells However, although the human body has a certain resistance function, once the immune function of the human body decreases, it may not be able to effectively resist and defeat these cancer cells, thus forming cancer Dr Daniel, deputy director of the University's Cancer Center, said: "this is a simple expression through random amino acid sequences in cells, so that cells can find active bioactive proteins for us." Cellular proteins are usually formed in hundreds of amino acid chains by the evolution of 20 amino acid combinations that make up the genetic alphabet The team wanted to know if they could create a short, biologically active protein that had never existed in cells, or had been discarded in natural selection They screened out thousands of artificial proteins that made up only 29 amino acid random sequences, and identified four new sequences that could produce new active proteins in the cell membrane These tiny proteins did not exist in nature When they were introduced into mice, they formed tumors, which proved that they had biological activity Daniel pointed out that the randomness of natural selection may lead to potential discarding of useful protein structures, which can be identified by using this screening technology These new protein forms can be used for many purposes, such as improving therapeutic response or developing new molecules, creating new biomaterials or waste disposal "We're going to get new insights into how proteins work, and we haven't yet considered making new products," Daniel said In addition, we may need to rethink the existing definition of genes, because cells can naturally express these small proteins, which is ignored ".