New research further reveals the "ins and outs" of cell differentiation and development

Xinhua News Agency, Chongqing, July 4 (Reporter Ke Gaoyang) How do cells differentiate and develop from primitive germ layers to tissues and organs? Chinese researchers used single-cell labeling and tracing technology to construct a whole-cell fate map of the zebrafish primitive foregut endoderm, further revealing the ins and outs of the development and maturation of cells from the primitive foregut to the tissues and organs
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Related research has recently been made, "US National Academy of Sciences published in the Academy of Sciences' online

"During the embryonic development of multicellular organisms, one precursor cell can eventually produce one or more types of mature functional cells
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" According to Luo Lingfei, the corresponding author of the paper and a professor at the School of Life Sciences of Southwest University, he clarified every precursor in the primitive germ layer.

To this end, Luo Lingfei's research team used fluorescent color-changing technology to label any single precursor cell in the zebrafish primitive foregut endoderm
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Because the progeny cells of the labeled cells inherit red fluorescence, researchers can visually "track" to determine the location and number of all progeny cells produced by the labeled precursor cells within 48 hours

Reviewers believe that the whole cell fate map constructed by this study will help the scientific community to further understand the cell fate determination and differentiation mechanism, and has important guiding significance for the study of functional cell differentiation in vitro and organ regeneration