New research has found clues to the evolution of the new coronavirus, or to help with vaccine design

A new virological study published in nature-structure and molecular biology, a professional academic journal of Springer Nature, says that by comparing the structure of the new coronavirus (SARS-CoV-2) and its close-edge bat virus RaTG13, which allows the virus to bind to cells and enter cells, it provides information for further understanding of the evolution of the new coronavirus hedgehog, which could be useful for vaccine design.
the paper, researchers believe the bat coronavirus may be an evolutionary premed for the new coronavirus, after previous studies found that the close relationship between the bat virus RaTG13 and the new coronavirus is the closest known. However, it is not clear how the new coronavirus evolved to infect humans, or whether it was transmitted directly to humans through an intermediate host.
paper's co-authors, Antoni Wrobel and Donald Benton, virologists at the Francis Crick Institute in London, UK, and colleagues found that although similar structures were similar, the form of the new coronavirus pyrethroid glycogen was more stable, about 1,000 times more affinity than the human-like protein ACE2.
they also found that the Flynn protease cut-off point on the new coronavirus sting may be beneficial to the virus because it may promote the virus's binding to receptors on cells. Based on these observations, the authors believe that bat viruses similar to RaTG13 are less likely to infect human cells, supporting the theory that the new coronavirus evolved after the genomes of different coronavirus were recombined.
authors note that the new coronavirus pyrethroids they studied are high-resolution, near-complete, and have more external loops than previously reported structures, which may be important for vaccine development and design. (Complete)