New research is helpful for early prevention and treatment of neuropathic pain

If the neuropathic pain is not treated in time, the development of chronic pain will have a greater impact on the quality of life of patients German researchers have reported that they have found a new way to inhibit neuropathic pain, which helps to prevent and treat the disease early Neuropathic pain induced by nervous system injury or disorder has always been a problem in the medical field Tingling, numbness and burning of hands and feet may be symptoms of neuropathic pain If chronic pain develops due to not timely treatment, the quality of life of patients will be greatly reduced due to long-term pain The researchers of Fraunhofer Institute of molecular biology and Applied Ecology in Germany have analyzed the mechanism of neuropathic pain, a statement said The nervous system will send "alarm" signals to the immune system in the case of injury, but when the immune cells are induced to the injured site, sometimes it will lead to long-term inflammation, which will cause continuous neuropathic pain, and eventually develop into chronic pain In this process, prostaglandin E2 is an important signal substance The commonly used painkillers, such as ibuprofen and diclofenac, have analgesic effect by inhibiting the production of prostaglandin E2 The researchers found another way to suppress pain To function, prostaglandin E2 needs to bind to a receptor that is highly related to a signaling molecule called CCL2 Studies have shown that when ibuprofen and other drugs fail to work, the use of antibodies to inhibit the function of CCL2 signaling molecules can also significantly reduce pain episodes The researchers said the method is expected to be used in the early prevention and treatment of neuropathic pain The results have been published in the American Journal of biochemistry.