New research shows that the combination of three drugs can overcome cross treatment resistance

Recently, a new study led by researchers from Brigham women's Hospital, published in the Journal of Science Signaling, shows that a combination of three drugs (http:// including a new glucose-6-phosphate dehydrogenase inhibitor, can overcome cross treatment resistance Researchers used computational models, in vitro experiments, in vivo animal models, clinical explants, human tumor models in vitro to explore the metabolic process of chemotherapy drug tolerance Based on Warburg's effect, the researchers observed that cancer cells absorbed extra glucose, causing the glycolysis pathway to overload But contrary to Warburg's effect, the researchers found increased mitochondrial activity, indicating a high oxygen consumption of cells Using mathematical models, the team found that in a time sensitive process, a combination of three drugs sensitized cancer cells In addition to these new drugs (http:// combinations of clinically available drugs can also be used to fight resistance, the researchers said The researchers acknowledge that they have not yet had a clear understanding of the plasticity of cancer cells, which allows them to acquire new metabolic phenotypes and develop resistance 】In the future, researchers hope to use mathematical models and machine learning to develop more and more accurate drug solutions to provide information for new cancer treatment.