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| New results achieve precise screening of prostate cancer |
Schematic diagram of sensor quantification of sarcosine for early prostate cancer screening image courtesy of the research group
Schematic diagram of sensor quantification of sarcosine for early prostate cancer screening image courtesy of the research group It is an urgent need of the medical profession to realize fast and simple early screening of cancer patients
.
Recently, Professor Gu Jinlou’s team from the School of Materials Science and Engineering at East China University of Science and Technology reported on a metal-organic framework based on a hierarchical structure of tunable mesopores.
Gu Jinlou’s team reported that a metal-organic framework with a hierarchical structure based on adjustable mesopores has achieved precise screening of prostate cancer patients (PCa) by constructing a sensor model for specific enzymatic reactions
To this end, researchers screened individuals for PCa by indirectly quantifying the sarcosine in clinical urine samples
.
The first author of the thesis, PhD student Zhao Liwei, told the Chinese Journal of Science that the strategy uses sarcosine oxidase (SOX) as a specific recognition unit and oxygen-sensitive molecules as signal reporters
Gu Jinlou said that this sensor model based on specific enzymatic reactions can effectively avoid the interference of structurally similar biomolecules
.
In addition, by changing the type of encapsulated enzyme, the concept of enzyme-assisted substrate sensing can be easily expanded
Related paper information: https://doi.
https://doi.
org/10.
1021/jacs.
1c05674
![9-[1,1'-biphenyl]-4-yl-3,3'-Bi-9H-carbazole](https://file.echemi.com/fileManage/upload/category/ac71ac0d-8ef6-11ec-89e5-fa163ed06441.png)
