[News] SARS-CoV-2 genome reveals the dynamics of the surge of alpha and beta variants in the UK

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Author: Joe Guide: Recently, the genome dynamic monitoring data of Alpha and Delta variants in the United Kingdom were published in the journal Nature.
The researchers came from the European Molecular Biology Laboratory European Biology Information Research Institute (EMBL-EBI) and Wellcome Sanger Research Institute
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At the same time, the research aims to monitor Alpha, Delta variants and other versions of mutated viruses to deal with uncertain future trends of the epidemic
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According to the latest research on the SARS-CoV-2 genome of the COVID-19 Genomics UK Consortium (COG-UK), the UK's COVID-19 has experienced multiple epidemics and sub-epidemics caused by different SARS-CoV-2 strains Sick
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Jeffrey Barrett, head of the COVID Genomics Initiative and co-senior and co-corresponding author of the Wellcome Sanger Institute’s COVID Genomics Initiative, said in a statement, “These genomic monitoring data provide us with a new way to observe the development of the epidemic.
It gives us a lot of knowledge about how new infectious pathogens spread and evolve
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" Jeffrey Barrett said: "My hope is that similar genome monitoring projects will be developed all over the world, so that we can do as well as possible.
Prepare for future outbreaks of infectious diseases-whether it is a familiar pathogen or a new pathogen
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"As they reported in the journal Nature on Thursday, the researchers came from the European Molecular Biology Laboratory, the European Institute for Bioinformatics (EMBL-EBI), and the Wellcome Sanger Institute
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From early September 2020 to the end of June 2021 Researchers collected nearly 281,200 SARS-CoV-2 isolates from 315 local health authorities in England and analyzed their genome sequences using systematic geographic analysis and other methods
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The
research team explained that the sequenced virus specimens It accounts for more than 7% of the number of PCR-positive samples identified in this time frame, spanning approximately 71 virus lineages, and its prevalence is constantly changing over time
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Through the analysis of the SARS-CoV-2 genome related to the geographical area , Researchers can trace the influx, spread, and interactions between new strains in different regions of the country
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Moritz Gerstung, a joint senior researcher and corresponding author of EMBL-EBI and the German Cancer Research Center, said in a statement: “We can see The side-by-side pedigrees, and mapping to specific locations, are incredibly informative in understanding how this series of epidemics unfolded
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"The authors also pointed out that during the broader COVID-19 pandemic, the COG-UK team has sequenced nearly 600,000 SARS-CoV-2 isolates
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They explained: "At the same time, under the same restrictions.
Next, among comparable populations, our intensive genome surveillance analysis identified a lineage that has consistently grown faster than others in each local health authority
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"For example, when the autumn of 2020 gradually enters the winter, the researchers found that the so-called Alpha variant of SARS-CoV-2 has increased in representativeness, and this variant appears to be more representative than the previously widely circulated lineage.
Communicative
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Despite the introduction of epidemic restrictions later in 2020, the Alpha mutant strain continues to spread, and the virus strain seems to have been suppressed in another stricter national "blockade" in early 2021
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Where Alpha variants and other leading lineages were found to cause the epidemic to lock down, other versions of the virus began to evolve forward, usually those mutations that changed the SARS-CoV-2 spike protein
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At the same time, these were largely replaced by a "Delta" SARS-CoV-2 variant, which gained a foothold and began to dominate with the relaxation of epidemic restrictions
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By the end of June, "Delta" accounted for approximately 98% of the SARS-CoV-2 variants detected in the region
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"These data show that in the fall of 2020, as Alpha and Delta variants sweep across the mainland of England, the strains show diversity," the author report said.
"Variants with fairly high heritability have the strongest positive selection.
It also swept England during the 10-month period of this investigation
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” The team pointed out that more monitoring and analysis are needed to maintain the label of other versions of the mutant virus in the human host population and adapt to the ever-increasing immunity.
Rate
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"Thanks to the genomic monitoring conducted in the UK and internationally, it is clear that the virus we are dealing with has changed a lot since we detected a variant in March 2020," the UK Health and Security Agency's COVID-19 Event director and co-author Meera Chand said in a statement, "We will continue to monitor the SARS-CoV-2 virus to ensure that we can use the most effective vaccines, therapeutic drugs and public health measures to combat current and future SARS.
-CoV-2 variants
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