Nitric oxide "scavengers" to target triple-negative breast cancer

Triple-negative breast cancer is an aggressive form of breast cancer that does not respond

"Nitric oxide is one of the major free radicals produced by tumor tissue," Amir explains, "at a certain concentration, it plays an important role

Nitric oxide interacts with different components in large networks of proteins and other molecules that surround, support, and make up the structure of tumor cells and tissues in vivo

Amir said: "HA plays a variety of roles

The ability

Overall, these results contribute to the understanding of HA's involvement in nitric oxide-induced cell migration and suggest the potential use of modified HA as a key material for different biomedical applications

Commenting on the study, Professor Abhay Pandit said: "While recent research on the role of nitric oxide in tumor progression has led to many ongoing clinical trials to assess the effects of nitric oxide synthase inhibitors, we are focusing on nitric oxide itself in an attempt to avoid side effects/reactions

Amir M.