Non-coding RNA molecules in cancer cells: stimulates the body's immune response.

In a recent study published in the international journal Proceedings of the National Academy of Sciences, researchers from the Icahn School of Medicine at Mount Sinai in the United States found that a class of non-coding RNA molecules in cancer cells can stimulate the triggering of an immune response in the body, which has similar properties to pathogens, and because they can be expressed and amplified in cancer, the body's immune response may affect the development of cancer.
the study began with the study of dark matter in the genome, a class of satellite DNA that produces large amounts of un-coded RNA ( ncRNA ) that do not produce proteins but have important regulatory effects ; Dr Benjamin Greenbaum points out that we have found large amounts of ncRNAs in cancer cells in humans and mice , and that scientists have slowly begun to find out that RNNCAs may also have important roles in the past five years .
cancers seem to be able to use these ncRNAs to stimulate the body's immune response, thereby promoting tumor growth and survival, but researchers do not yet know the specific function of ncRNAs; future studies may define such molecules as helping to develop cancer, although ncRNAs molecules can also be targeted to suppress other molecules or use RNNCAs as markers to understand cancer progression.
now several research groups have begun to use mathematical tools based on theoretical physics to study the role of ncRNA dark matter, Greenbaum said, we searched the ncRNA database of large nucleotide patterns, and if we liken nucleotide sequences to words, some words in the human genome may not be representative, so we want to study how these patterns differ in RNA transcription in cancer cells, and relevant research methods can help us to do large-scale database analysis faster.
researchers have found in a variety of cancers that strange RNAs can be activated or transcribed, and these unusual RNAs can be used in a number of ways, i.e. multiple copies of RNAs are actually much larger than normal cells.
concluded that these ncRNAs have rare patterns, similar to pathogens, that stimulate the body to produce congenital immune responses, and the researchers believe that these ncRNAs may play an important role in mediating the immune response to cancer, although much work is needed later in the process, and researchers are interested in continuing to delve into this.
Source: Decoding Medicine.