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Novartis terminates phase II study of CD40 monoclonal antibody iscalimab for kidney transplant rejection

 Last Update: 2021-09-12
 Source: Internet
 Author: User

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On the 3rd, Novartis announced the termination of a CIRRUS-1 study of CFZ533 (iscalimab) for the prevention of organ transplant rejection in kidney transplant patients

The results of the interim analysis showed that CFZ533 (iscalimab) is not as effective as tacromol in preventing organ transplant rejection in combination with other immunosuppressive agents (induction therapy, mycophenolate mofetil and corticosteroids) for patients undergoing kidney transplantation Division

Iscalimab is modified from lucatumumab and introduces N297A mutation in the Fc region, thereby losing the ability to bind to FcγR, without Fc-mediated effects

Clinical trials of CFZ533 for patients undergoing liver transplantation, hidradenitis suppurativa, Sjogren’s syndrome and other indications are still in progress

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